about
From docking false-positive to active anti-HIV agent.mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae[d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase.Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.C-2-aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors.Optimization of azoles as anti-human immunodeficiency virus agents guided by free-energy calculations.R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activityDefining a molecular mechanism of synergy between nucleoside and nonnucleoside AIDS drugs.[d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor.Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy.Modulation of human immunodeficiency virus type 1 synergistic inhibition by reverse transcriptase mutations.Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase.FEP-guided selection of bicyclic heterocycles in lead optimization for non-nucleoside inhibitors of HIV-1 reverse transcriptaseOptimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptaseMechanism of action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl) thymine as an anti-HIV agent
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Christopher M Bailey
@ast
Christopher M Bailey
@en
Christopher M Bailey
@es
Christopher M Bailey
@nl
Christopher M Bailey
@sl
type
label
Christopher M Bailey
@ast
Christopher M Bailey
@en
Christopher M Bailey
@es
Christopher M Bailey
@nl
Christopher M Bailey
@sl
prefLabel
Christopher M Bailey
@ast
Christopher M Bailey
@en
Christopher M Bailey
@es
Christopher M Bailey
@nl
Christopher M Bailey
@sl
P106
P21
P31
P496
0000-0002-5962-9511