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Calcitonin receptor plays a physiological role to protect against hypercalcemia in miceOsteoblast-chondrocyte interactions in osteoarthritisRelationship between serum RANKL and RANKL in boneOsteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorptionBril: a novel bone-specific modulator of mineralizationSclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathwayPharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer.TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis.Skeletal characterization of an osteoblast-specific vitamin D receptor transgenic (ObVDR-B6) mouse model.Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma.Characterization of drug-release kinetics in trabecular bone from titania nanotube implants.Anticancer efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in osteolytic breast cancer murine models.The skeleton as an intracrine organ for vitamin D metabolism.Vitamin D metabolism within bone cells: effects on bone structure and strength.An update on primary hip osteoarthritis including altered Wnt and TGF-β associated gene expression from the bony component of the disease.Osteocyte regulation of bone mineral: a little give and take.The pleiotropic effects of vitamin D in bone.Modulation of osteoclastic migration by metabolism of 25OH-vitamin D3.Extracellular phosphate modulates the effect of 1α,25-dihydroxy vitamin D3 (1,25D) on osteocyte like cells.Novel targets of vitamin D activity in bone: action of the vitamin D receptor in osteoblasts, osteocytes and osteoclasts.Analysis of vitamin D metabolism gene expression in human bone: evidence for autocrine control of bone remodelling.The local production of 1,25(OH)2D3 promotes osteoblast and osteocyte maturation.Periprosthetic osteolysis after total hip replacement: molecular pathology and clinical management.Vitamin D receptor overexpression in osteoblasts and osteocytes prevents bone loss during vitamin D-deficiency.The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro.Evidence for altered osteoclastogenesis in splenocyte cultures from VDR knockout mice.Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer.Peroxidase enzymes inhibit osteoclast differentiation and bone resorption.Drug-releasing nano-engineered titanium implants: therapeutic efficacy in 3D cell culture model, controlled release and stability.Osteocytes: The master cells in bone remodelling.Postoperative weight bearing and patient reported outcomes at one year following tibial plateau fractures.Comparison of the biological effects of exogenous and endogenous 1,25-dihydroxyvitamin D3 on the mature osteoblast cell line MLO-A5.Early response of the human SOST gene to stimulation by 1α,25-dihydroxyvitamin D3.1α,25-dihydroxyvitamin D3 stimulates human SOST gene expression and sclerostin secretion.1,25-Dihydroxyvitamin D3 and extracellular calcium promote mineral deposition via NPP1 activity in a mature osteoblast cell line MLO-A5.Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli.SaOS2 Osteosarcoma cells as an in vitro model for studying the transition of human osteoblasts to osteocytes.Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2.The metabolism of 25-(OH)vitamin D3 by osteoclasts and their precursors regulates the differentiation of osteoclasts.Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts.
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description
onderzoeker
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researcher
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հետազոտող
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name
Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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Gerald J Atkins
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P106
P1153
7102660859
P31
P496
0000-0002-3123-9861