about
Synthetic Approaches toward Monocyclic 3-Amino-β-lactamsDiscovery of anxiolytic 2-ferrocenyl-1,3-thiazolidin-4-ones exerting GABAA receptor interaction via the benzodiazepine-binding site.Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors.Regioselectivity in the ring opening of non-activated aziridines.Quinoline-based antimalarial hybrid compounds.Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors.Exploration of thiaheterocyclic hHDAC6 inhibitors as potential antiplasmodial agents.Synthesis and anticancer properties of new (dihydro)pyranonaphthoquinones and their epoxy analogs.Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors.Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity.Synthesis of halogenated 4-quinolones and evaluation of their antiplasmodial activity.N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis.Evaluation of (4-aminobutyloxy)quinolines as a novel class of antifungal agents.Reactivity of 3-Oxo-β-lactams with Respect to Primary Amines-An Experimental and Computational Approach.Asymmetric Synthesis of 3,4-Disubstituted 2-(Trifluoromethyl)pyrrolidines through Rearrangement of Chiral 2-(2,2,2-Trifluoro-1-hydroxyethyl)azetidines.Theoretical insight into the regioselective ring-expansions of bicyclic aziridinium ions.Antibacterial and β-Lactamase Inhibitory Activity of Monocyclic β-Lactams.Exploration of aziridine- and β-lactam-based hybrids as both bioactive substances and synthetic intermediates in medicinal chemistry.Formation of Fluorinated Amido Esters through Unexpected C3-C4 Bond Fission in 4-Trifluoromethyl-3-oxo-β-lactams.Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates.Biocatalytic production of novel glycolipids with cellodextrin phosphorylase.Reactivity of activated versus nonactivated 2-(bromomethyl)aziridines with respect to sodium methoxide: a combined computational and experimental study.Engineering the specificity of trehalose phosphorylase as a general strategy for the production of glycosyl phosphates.Converting bulk sugars into prebiotics: semi-rational design of a transglucosylase with controlled selectivity.Cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to versatile β-lactam building blocks.Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A.Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams.Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH₄-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl)aziridines and evaluation of their antimalarial activity.Synthesis of Potent and Selective HDAC6 Inhibitors Bearing a Cyclohexane- or Cycloheptane-Annulated 1,5-Benzothiazepine Scaffold.Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones.Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase.Synthesis of Novel Aza-aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines.Chemoenzymatic Approach toward the Synthesis of 3-O-(α/β)-Glucosylated 3-Hydroxy-β-lactamsA nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-onesSynthesis and Applications of 3-Methylene-4-(trifluoromethyl)azetidin-2-ones as Building Blocks for the Preparation of Mono- and Spirocyclic 4-CF3 -β-LactamsSynthesis of piperidin-4-ones starting from 2-(2-bromo-1,1-dimethylethyl)azetidines and 2-(2-mesyloxyethyl)azetidines through a ring expansion–oxidation protocolSynthesis of Non-Symmetrical Nitrogen-Containing Curcuminoids in the Pursuit of New Anticancer CandidatesChemical and enzymatic synthesis of 2-(2-carbamoylethyl)- and 2-(2-carboxyethyl)aziridines and their conversion into δ-lactams and γ-lactonesNucleophile-dependent regio- and stereoselective ring opening of 1-azoniabicyclo[3.1.0]hexane tosylateIn Silico Design and Enantioselective Synthesis of Functionalized Monocyclic 3-Amino-1-carboxymethyl-β-lactams as Inhibitors of Penicillin-Binding Proteins of Resistant Bacteria
P50
Q33809979-22E8B792-E6C5-440C-8EF3-41801DD46B47Q35192338-9C332BD8-2E53-40A0-B0F1-C88054BD09DAQ35637328-F9DEBF8A-ECEA-4617-A8DA-1598C1B09999Q37926925-A21EB9A0-41F7-40D0-9C47-178B5F04AE2AQ38320168-C523A0FF-12C2-49D7-89F4-BC91C2A50FBBQ38689713-B2796105-E09E-4854-A11A-0B5EFCABDC26Q38750220-94FD98BE-3695-49F3-B9D0-C92B93D53C02Q38863291-D59A20F7-379C-40DB-B9EC-B43C56BDB684Q40047077-8ACA519D-9282-421E-ABE1-4B41E6B18FA5Q41579052-2A70A1CF-80D8-4730-89A5-5647F06453DFQ41922585-074F9DE0-AC97-4F22-A384-3FC612F93FEFQ41960536-AC3EF8E8-4F37-4F7F-B4F9-8CB1FE53E800Q44238595-F07984F7-08C8-4005-AB7B-51235668FCFDQ47575983-A35D7949-6D78-4A69-93C6-5144E81C88BFQ47738288-FFCCC61D-3B6D-473F-9FEE-2DD71E5BEC59Q47738743-6EFB91C4-CD18-4726-948F-1BBE3E3BF526Q47786477-22B3200A-6CD1-4497-B184-96A6E4B7EC01Q47887332-EF463F07-B3D1-4757-9AA9-25B37233ED44Q48279122-3E90666C-214A-4602-8101-95C26B7CBCECQ49033736-12E1F7A1-A77A-400C-94B0-55A754E6A221Q49045316-CC83ECFF-22C7-4432-A1DA-3CC26E6FF745Q49046346-CDAC30AB-491C-470E-8A63-7486185F0231Q49065208-7487E077-984A-49F7-83D1-21EC4DF33F5CQ49074285-55143CF3-AF39-4EFB-83DC-7A988FA4E3C9Q49093130-865CE1F3-F80A-421C-B03E-1F10FB1F767BQ49131145-E2D0FBE4-48DD-4A02-98AB-DEEA8071B07FQ49136764-5BCF8FE4-D549-4B61-897D-309426679798Q49138626-465B2401-C710-4375-8EB8-97417B66B163Q49149016-55F230A5-F3D0-4EB3-A370-2B5D0B92F1DAQ49161840-11DE3C40-FE31-4322-9118-53306D2D5219Q52690084-23035968-0749-48A6-8CE2-204A06F38DBBQ54975677-77467200-874F-4A02-83E1-DC98C64E2741Q59809615-904C1C06-EE9E-47CF-AED4-CE77F3BE3F88Q61465001-8E02EA05-349A-4E91-B971-4A0FAEBB9889Q61465003-F8349362-A229-451E-934F-966525BA2C21Q61465017-E6B95D6F-05DA-44FC-9B88-FAD5C26D38BEQ64094249-680C3C72-838E-41D2-AC33-4B5ED942F5ABQ82846162-0FFD3CDE-66CA-4734-8975-F3808076984AQ87218139-5A57EC3A-D0C5-4573-896E-300E155AEC86Q89038877-A31D6BB2-6C34-43F2-BB43-59A7058CFF54
P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Matthias D'hooghe
@ast
Matthias D'hooghe
@en
Matthias D'hooghe
@es
Matthias D'hooghe
@nl
type
label
Matthias D'hooghe
@ast
Matthias D'hooghe
@en
Matthias D'hooghe
@es
Matthias D'hooghe
@nl
prefLabel
Matthias D'hooghe
@ast
Matthias D'hooghe
@en
Matthias D'hooghe
@es
Matthias D'hooghe
@nl
P106
P108
P21
P31
P496
0000-0002-4442-4337