about
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.Structural and Functional Studies of Aspergillus oryzae Cutinase: Enhanced Thermostability and Hydrolytic Activity of Synthetic Ester and Polyester DegradationMolecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome ActivationCrystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED InteractionsStructural mechanisms of inflammasome assemblyPlasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain FilamentsA single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assemblyHeat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1SERPINB1-mediated checkpoint of inflammatory caspase activationMolecular mechanism for NLRP6 inflammasome assembly and activation
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Alvin Lu
@ast
Alvin Lu
@en
Alvin Lu
@es
Alvin Lu
@nl
type
label
Alvin Lu
@ast
Alvin Lu
@en
Alvin Lu
@es
Alvin Lu
@nl
prefLabel
Alvin Lu
@ast
Alvin Lu
@en
Alvin Lu
@es
Alvin Lu
@nl
P106
P31
P496
0000-0003-2353-848X