about
Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage.Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindleCellular contractility requires ubiquitin mediated proteolysisA first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain constructDifferential control of Eg5-dependent centrosome separation by Plk1 and Cdk1Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.Cdk activity couples epigenetic centromere inheritance to cell cycle progression.Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells.PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.Post-replication repair in DT40 cells: translesion polymerases versus recombinases.Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage.Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.Differential usage of non-homologous end-joining and homologous recombination in double strand break repair.DNA synthesis is required for reprogramming mediated by stem cell fusionProteomics of a fuzzy organelle: interphase chromatin.PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage.Bistability of mitotic entry and exit switches during open mitosis in mammalian cells.Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics.An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells.DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2.Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase.Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair-deficient cells.Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends.Critical roles for polymerase zeta in cellular tolerance to nitric oxide-induced DNA damage.Interlinked bistable mechanisms generate robust mitotic transitions.Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.Cyclin-dependent kinases and cell-cycle transitions: does one fit all?Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian CellsLive imaging of marked chromosome regions reveals their dynamic resolution and compaction in mitosisDNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation.Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosisTriggering mitosisCyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Helfrid Hochegger
@ast
Helfrid Hochegger
@en
Helfrid Hochegger
@es
Helfrid Hochegger
@nl
type
label
Helfrid Hochegger
@ast
Helfrid Hochegger
@en
Helfrid Hochegger
@es
Helfrid Hochegger
@nl
prefLabel
Helfrid Hochegger
@ast
Helfrid Hochegger
@en
Helfrid Hochegger
@es
Helfrid Hochegger
@nl
P106
P1153
8555753900
P31
P496
0000-0001-8366-6198