about
α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in micePerlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTENPrestress in the extracellular matrix sensitizes latent TGF-β1 for activation.Perlecan maintains microvessel integrity in vivo and modulates their formation in vitroIntegrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis.Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrowThe fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes.Profilin1 is expressed in osteocytes and regulates cell shape and migration.Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease.Structural and cell-adhesive properties of three recombinant fragments derived from perlecan domain III.Profilin1 activity in cerebellar granule neurons is required for radial migration in vivo.Engineered microenvironments for synergistic VEGF - Integrin signalling during vascularization.Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice.Structural characterization of recombinant domain II of the basement membrane proteoglycan perlecan.Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second.Purkinje cell loss and motor coordination defects in profilin1 mutant mice.Perlecan is critical for heart stability.Profilin 1 is required for peripheral nervous system myelination.Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice.Changes in the integrins expression are related with the osteoarthritis severity in an experimental animal model in ratsA smaller initial dose protects mice against several lethal doses of ammonium acetateThe potentiation of ammonia toxicity by sodium benzoate is prevented by L-carnitineEffect of L-carnitine on ketone bodies, redox state and free amino acids in the liver of hyperammonemic miceInfluence of the route of administration on the protective effect of L-carnitine on acute hyperammonemiaAge-dependent decrease of carnitine content in muscle of mice and humansCarbamyl glutamate prevents the potentiation of ammonia toxicity by sodium benzoateDecarbamoylating activity of ornithine transcarbamoylaseEffects of L-carnitine on urea synthesis following acute ammonia intoxication in miceEffect of carnitine feeding on the levels of heart and skeletal muscle carnitine of elderly micePrevention of ammonia toxicity by L-carnitine: metabolic changes in brainProtective effect of L-carnitine on hyperammonemiaDevelopment of the coronary arteries in a murine model of transposition of great arteriesInhibition of glycosaminoglycan modification of perlecan domain I by site-directed mutagenesis changes protease sensitivity and laminin-1 binding activityα-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarityIntegrin activation by talin, kindlin and mechanical forces
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Mercedes Costell
@ast
Mercedes Costell
@en
Mercedes Costell
@es
Mercedes Costell
@nl
type
label
Mercedes Costell
@ast
Mercedes Costell
@en
Mercedes Costell
@es
Mercedes Costell
@nl
prefLabel
Mercedes Costell
@ast
Mercedes Costell
@en
Mercedes Costell
@es
Mercedes Costell
@nl
P106
P1153
56724655600
P31
P496
0000-0001-6146-996X