about
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3betaTranslational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient StressIdentification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical libraryInducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptorThioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cellsIn vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damageRegulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptorThe cell biology of the unfolded protein response.Effects on protein synthesis produced by pairing depolarization with serotonin, an analogue of associative learning in Aplysia.Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress.Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcomaCell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapyThe PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation.The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.In Vivo Interrogation of the Hypoxic Transcriptome of Solid Tumors: Optimizing Hypoxic Probe Labeling with Laser Capture Microdissection for Isolation of High-Quality RNA for Deep Sequencing Analysis.Control of the hypoxic response through regulation of mRNA translation.Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia.miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.ER stress, hypoxia tolerance and tumor progression.GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235The chemopreventive and clinically used agent curcumin sensitizes HPV (-) but not HPV (+) HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model.Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progressionc-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastomamiR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosisAMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer TreatmentActivating transcription factor 4 is translationally regulated by hypoxic stress.ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis.Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.PERK-ing up autophagy during MYC-induced tumorigenesis.Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses.Effects of radiation quality and oxygen on clustered DNA lesions and cell death.Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab.
P50
Q24306430-93FB3517-FFCB-4FA9-AA13-0ECF899DF4BCQ24338238-16F6510C-C6B9-40FD-8E89-B90408D699A9Q33299295-2878A4B1-4E70-465C-A568-69460F19B362Q33593849-AE7E88D2-93C5-48D8-ACA6-C58D1C1F9D51Q33699108-FD1B2A62-E751-4640-820D-05B5FAD549BEQ33803567-6A1EE7F1-8C94-49E7-A498-71E6DC76264FQ33865148-7E13C644-D81E-42CE-9C69-E77806841501Q33977034-BF1296A8-366D-4AF2-A097-271760CC1037Q34011633-5A0E25EE-8AE0-482B-9B0B-522ADC07421FQ34508154-6B93E656-B3C0-433F-9493-D2D2E6FEBC90Q35063016-C3B00C61-0D49-4553-8E39-424EFC16B7D9Q35085852-988733B2-C802-4704-BE6E-4A1909D4F0EBQ35218247-958575F9-582F-4434-A0E9-2219472DA201Q35221396-508F051D-02A8-4AE5-82E9-92054FDF370EQ35680861-597C8FCD-BC44-43B7-9214-D26E934732BEQ35796921-CB81915A-C3A0-4345-ABC2-EBB9BBB581F5Q35912293-DF4C94C2-BAD8-4AC0-8568-BC384307B06CQ35930433-45CBE7CB-880C-47BB-AE5A-424ECF890104Q35932187-86DBA4A1-319B-4FE2-967E-DF0C2880BC09Q36040206-B815DDFE-DC5B-468E-A0D3-D0E0DBF91EB3Q36057395-75058B89-3857-4A2A-867E-4087A38E71E8Q36129275-78F85909-B132-4ADC-8895-F06D8BF82DF6Q36289917-677A2AEE-94F1-4BFF-95B2-644A04538B53Q36392923-DCCA5D96-9E44-42F8-AFC8-2EC6E2D070B9Q36393499-5CB544D4-E9D7-46AD-B100-6A1B299FE5F3Q36406359-1B5E90D7-AA16-465A-B7D5-79F81C5F0514Q36412815-6B6C0E6A-8749-4A4E-815A-AFE51C7EC9FFQ36504144-D7A7DF9E-0B12-4470-B09B-B5153B7CD6A0Q36784394-C7268554-F607-4856-BF19-8786F0843BB8Q36867324-61E69127-AE8C-411D-8CF3-CA2A4BAE4931Q36906971-941282E9-3308-48BE-8422-A94158CEC26DQ36976172-8B6740A9-0D6C-483C-8D3E-7BB1D054B881Q37349289-932CCA9B-6F2B-4FEE-A32D-81387B8C1433Q37515795-3954E978-C8B6-49D7-AD58-448AE49AA812Q38673432-C0E9A1D8-1CF1-44E0-B178-B93757BCF4DEQ39020884-30FE5BA6-6A0A-475E-86A3-91F9A43BA236Q39208856-54C8F822-2361-4496-8342-38189126991EQ39264002-D657888B-7189-4C6F-8E30-2E009993D539Q39493436-844ABC95-B8DB-4E67-BBCE-01995C7468F3Q39514897-148C8D81-778E-4A1D-95D3-1C7BB71E6FAF
P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Costas Koumenis
@ast
Costas Koumenis
@en
Costas Koumenis
@es
Costas Koumenis
@nl
type
label
Costas Koumenis
@ast
Costas Koumenis
@en
Costas Koumenis
@es
Costas Koumenis
@nl
prefLabel
Costas Koumenis
@ast
Costas Koumenis
@en
Costas Koumenis
@es
Costas Koumenis
@nl
P106
P1153
6701825171
P31
P496
0000-0001-5945-4726