Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes
about
N-myristoyltransferase inhibitors as new leads to treat sleeping sicknessStructure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunityHydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomesImmune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to PathogenicityThe Trypanosome Flagellar Pocket Collar and Its Ring Forming Protein-TbBILBO1How Does the VSG Coat of Bloodstream Form African Trypanosomes Interact with External Proteins?The Flagellum Attachment Zone: 'The Cellular Ruler' of Trypanosome MorphologyForm, Fabric, and Function of a Flagellum-Associated Cytoskeletal StructureImaging African trypanosomesIntravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomesSpecies-Specific Adaptations of Trypanosome Morphology and Motility to the Mammalian HostThree-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical springSimulating the complex cell design of Trypanosoma brucei and its motilityNovel African trypanocidal agents: membrane rigidifying peptidesN-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding thresholdImpact of microscopic motility on the swimming behavior of parasites: straighter trypanosomes are more directionalTrypanosome motion represents an adaptation to the crowded environment of the vertebrate bloodstreamBromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African TrypanosomeCrystal structure of the small GTPase Arl6/BBS3 fromTrypanosoma bruceiBlocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat AntibodiesThe limits on trypanosomatid morphological diversityStructure of the TbBILBO1 protein N-terminal domain from Trypanosoma brucei reveals an essential requirement for a conserved surface patch.Mouse infection and pathogenesis by Trypanosoma brucei motility mutantsThree-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomographyMembrane domains and flagellar pocket boundaries are influenced by the cytoskeleton in African trypanosomes.Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation.Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks.The plasma membrane of bloodstream-form African trypanosomes confers susceptibility and specificity to killing by hydrophobic peptidesA cell-body groove housing the new flagellum tip suggests an adaptation of cellular morphogenesis for parasitism in the bloodstream form of Trypanosoma brucei.Motility and more: the flagellum of Trypanosoma brucei.Shedding of host autophagic proteins from the parasitophorous vacuolar membrane of Plasmodium berghei.Determinants of GPI-PLC localisation to the flagellum and access to GPI-anchored substrates in trypanosomesBiogenesis of the trypanosome endo-exocytotic organelle is cytoskeleton mediated.The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages.The trypanosome Rab-related proteins RabX1 and RabX2 play no role in intracellular trafficking but may be involved in fly infectivity.Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.Evidence that low endocytic activity is not directly responsible for human serum resistance in the insect form of African trypanosomesLineage-specific proteins essential for endocytosis in trypanosomes.The endocytic activity of the flagellar pocket in Trypanosoma brucei is regulated by an adjacent phosphatidylinositol phosphate kinase.The paraflagellar rod of kinetoplastid parasites: from structure to components and function
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P2860
Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes
description
im November 2007 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в листопаді 2007
@uk
name
Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes
@en
Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes
@nl
type
label
Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes
@en
Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes
@nl
prefLabel
Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes
@en
Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes
@nl
P2093
P1433
P1476
Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes
@en
P2093
Geert Wiegertjes
Markus Engstler
Michael Boshart
Niko Heddergott
Peter Overath
P304
P356
10.1016/J.CELL.2007.08.046
P407
P577
2007-11-01T00:00:00Z