Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades
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A hidden feedback in signaling cascades is revealedRoles of protein ubiquitination and degradation kinetics in biological oscillationsIntegrative modelling of the influence of MAPK network on cancer cell fate decisionPositive feedback promotes oscillations in negative feedback loopsData-derived modeling characterizes plasticity of MAPK signaling in melanomaTailored parameter optimization methods for ordinary differential equation models with steady-state constraintsAn attempt to construct a (general) mathematical framework to model biological "context-dependence".Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.Ultrasensitive response motifs: basic amplifiers in molecular signalling networks.Robust and efficient parameter estimation in dynamic models of biological systemsRelaxation oscillations and hierarchy of feedbacks in MAPK signalingCellFrame: a data structure for abstraction of cell biology experiments and construction of perturbation networks.Developing complex signaling models using GENESIS/Kinetikit.Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins.Signaling cascades modulate the speed of signal propagation through space.Positional information generated by spatially distributed signaling cascades.Automated ensemble modeling with modelMaGe: analyzing feedback mechanisms in the Sho1 branch of the HOG pathway.Oscillation dynamics underlie functional switching of NF-κB for B-cell activation.Unraveling the design principle for motif organization in signaling networksEmploying a Mechanistic Model for the MAPK Pathway to Examine the Impact of Cellular all or None Behavior on Overall Tissue Response.Untangling the wires: a strategy to trace functional interactions in signaling and gene networks.Biochemical fluctuations, optimisation and the linear noise approximationUnderstanding regulation of metabolism through feasibility analysis.Modeling and experimental analyses reveals signaling plasticity in a bi-modular assembly of CD40 receptor activated kinases.When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise.Likelihood based observability analysis and confidence intervals for predictions of dynamic modelsLineage grammars: describing, simulating and analyzing population dynamics.Random parameter sampling of a generic three-tier MAPK cascade model reveals major factors affecting its versatile dynamics.All-Trans Retinoic Acid Induces TGF-β2 in Intestinal Epithelial Cells via RhoA- and p38α MAPK-Mediated Activation of the Transcription Factor ATF2.Cross-talk in abscisic acid signaling.Determinants of cell-to-cell variability in protein kinase signaling.Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling.Hierarchical feedback modules and reaction hubs in cell signaling networks.Pycellerator: an arrow-based reaction-like modelling language for biological simulations.DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks.A spectrum of models of signaling pathways.Intrinsic noise alters the frequency spectrum of mesoscopic oscillatory chemical reaction systems.Scaffold proteins confer diverse regulatory properties to protein kinase cascades.Signalling by protein phosphatases and drug development: a systems-centred view.
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Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades
description
im März 2000 veröffentlichter wissenschaftlicher Artikel
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scientific article published on 01 March 2000
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wetenschappelijk artikel
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наукова стаття, опублікована в березні 2000
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name
Negative feedback and ultrasen ...... ivated protein kinase cascades
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Negative feedback and ultrasen ...... ivated protein kinase cascades
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type
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Negative feedback and ultrasen ...... ivated protein kinase cascades
@en
Negative feedback and ultrasen ...... ivated protein kinase cascades
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prefLabel
Negative feedback and ultrasen ...... ivated protein kinase cascades
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Negative feedback and ultrasen ...... ivated protein kinase cascades
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P1433
P1476
Negative feedback and ultrasen ...... ivated protein kinase cascades
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P304
P356
10.1046/J.1432-1327.2000.01197.X
P407
P577
2000-03-01T00:00:00Z