US2, a Human Cytomegalovirus-encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide
about
A membrane protein required for dislocation of misfolded proteins from the ERProtein disulphide isomerase is required for signal peptide peptidase-mediated protein degradationA glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised.The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologySignal peptide peptidase is required for dislocation from the endoplasmic reticulumProcessing of human cytomegalovirus UL37 mutant glycoproteins in the endoplasmic reticulum lumen prior to mitochondrial importation.Binding of human cytomegalovirus US2 to major histocompatibility complex class I and II proteins is not sufficient for their degradation.Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis.SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond.SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteinsA bipartite trigger for dislocation directs the proteasomal degradation of an endoplasmic reticulum membrane glycoproteinHuman cytomegalovirus (HCMV) US2 protein interacts with human CD1d (hCD1d) and down-regulates invariant NKT (iNKT) cell activity.Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions.Classical and non-classical MHC I molecule manipulation by human cytomegalovirus: so many targets—but how many arrows in the quiver?Selenoprotein S is involved in maintenance and transport of multiprotein complexes.Long-lived signal peptide of lymphocytic choriomeningitis virus glycoprotein pGP-C.
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P2860
US2, a Human Cytomegalovirus-encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Januar 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
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wetenschappelijk artikel
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наукова стаття, опублікована в січні 2002
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name
US2, a Human Cytomegalovirus-e ...... Amino-terminal Signal Peptide
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US2, a Human Cytomegalovirus-e ...... Amino-terminal Signal Peptide
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type
label
US2, a Human Cytomegalovirus-e ...... Amino-terminal Signal Peptide
@en
US2, a Human Cytomegalovirus-e ...... Amino-terminal Signal Peptide
@nl
prefLabel
US2, a Human Cytomegalovirus-e ...... Amino-terminal Signal Peptide
@en
US2, a Human Cytomegalovirus-e ...... Amino-terminal Signal Peptide
@nl
P2860
P356
P1476
US2, a Human Cytomegalovirus-e ...... Amino-terminal Signal Peptide
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P2093
Benjamin E. Gewurz
Hidde L. Ploegh
P2860
P304
11306-11313
P356
10.1074/JBC.M107904200
P407
P577
2002-01-14T00:00:00Z