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Considerations on the Mechanism of Action of Artemisinin Antimalarials: Part 1 - The 'Carbon Radical' and 'Heme' HypothesesArtemisinin Antimalarials Do Not Inhibit Hemozoin FormationExpression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor ClassesA single amino acid residue can determine the sensitivity of SERCAs to artemisininsA single amino acid residue can determine the sensitivity of SERCAs to artemisininsA Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of ChloroquineArtemisinins: their growing importance in medicineGlucocorticosteroids in nano-sterically stabilized liposomes are efficacious for elimination of the acute symptoms of experimental cerebral malariaAnticancer properties of distinct antimalarial drug classesArtesunate and dihydroartemisinin (DHA): unusual decomposition products formed under mild conditions and comments on the fitness of DHA as an antimalarial drug.Elimination of Schistosoma mansoni in infected mice by slow release of artemisone.Reactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified.Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses.Artemisone effective against murine cerebral malariaRecent progress in the development of anti-malarial quinolones.Possible modes of action of the artemisinin-type compounds.Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivaxArtemisone uptake in Plasmodium falciparum-infected erythrocytes.Artemisinin and derivatives: the future for malaria treatment?A quantitative reverse-transcriptase PCR assay for the assessment of drug activities against intracellular Theileria annulata schizontsSynthesis of artemiside and its effects in combination with conventional drugs against severe murine malariaArtemisinins: mechanisms of action and potential for resistance.Artemisinins: activities and actions.From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements.Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse modelEvaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum.Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine modelThe Case for Development of 11-Aza-artemisinins for Malaria.In vitro skin permeation of artemisone and its nano-vesicular formulations.In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells.Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives.Preparation of N-sulfonyl- and N-carbonyl-11-azaartemisinins with greatly enhanced thermal stabilities: in vitro antimalarial activities.Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle.Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo.Neurotoxic mode of action of artemisinin.Neospora caninum: in vivo and in vitro treatment with artemisone.In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents.Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins.Differential effects on angiogenesis of two antimalarial compounds, dihydroartemisinin and artemisone: implications for embryotoxicity.In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori.
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P50
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wetenschapper
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հետազոտող
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Richard K Haynes
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Richard K Haynes
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Richard K Haynes
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Richard K Haynes
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Richard K Haynes
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Richard K Haynes
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Richard K Haynes
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Richard K Haynes
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Richard K Haynes
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Richard K Haynes
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Richard K Haynes
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Richard K Haynes
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