about
Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistantDecreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase IAdvantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study.Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers.Specific detection of topoisomerase I from the malaria causing P. falciparum parasite using isothermal rolling circle amplification.Rolling circle amplification-based detection of human topoisomerase I activity on magnetic beads.Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement.A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism.Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico.Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant.Interaction between natural compounds and human topoisomerase I.Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin.Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity.Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene.Erybraedin C, a natural compound from the plant Bituminaria bituminosa, inhibits both the cleavage and religation activities of human topoisomerase I.Real-time analysis of cleavage and religation activity of human topoisomerase 1 based on ternary fluorescence resonance energy transfer DNA substrate.Microfluidics-Enabled Enzyme Activity Measurement in Single Cells.On-slide detection of enzymatic activities in selected single cells.The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation.Isolation of functional mitochondria by inertial microfluidics – a new method to sort intracellular organelles from a small scale biological sampleRefined Method for Droplet Microfluidics-Enabled Detection of Plasmodium falciparum Encoded Topoisomerase I in Blood from Malaria PatientsMutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientationThe human DNA topoisomerase I mutant Gly717Asp: Higher religation rate is not always associated with camptothecin resistance
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Cinzia Tesauro
@ast
Cinzia Tesauro
@en
Cinzia Tesauro
@es
Cinzia Tesauro
@nl
type
label
Cinzia Tesauro
@ast
Cinzia Tesauro
@en
Cinzia Tesauro
@es
Cinzia Tesauro
@nl
prefLabel
Cinzia Tesauro
@ast
Cinzia Tesauro
@en
Cinzia Tesauro
@es
Cinzia Tesauro
@nl
P106
P1153
18435424200
P31
P496
0000-0003-2986-9618