about
Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferaseThe C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding ModuleSynthesis of α-Glucan in Mycobacteria Involves a Hetero-octameric Complex of Trehalose Synthase TreS and Maltokinase Pep2Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitorsExpression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosisBiochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetaseBiochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug targetDeletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan-deficient mutant with a cell wall galactan core.Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant.A truncated lipoglycan from mycobacteria with altered immunological properties.Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorusMolecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.Topology and mutational analysis of the single Emb arabinofuranosyltransferase of Corynebacterium glutamicum as a model of Emb proteins of Mycobacterium tuberculosis.Activity of Bdellovibrio hit locus proteins, Bd0108 and Bd0109, links Type IVa pilus extrusion/retraction status to prey-independent growth signalling.Non-replicating Mycobacterium tuberculosis elicits a reduced infectivity profile with corresponding modifications to the cell wall and extracellular matrix.Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors.Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB' mutant.Regulation of cell wall synthesis and growth.Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new drug targets.Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis.Tuberculosis: a balanced diet of lipids and carbohydrates.Disruption of Mycobacterial AftB Results in Complete Loss of Terminal β(1 → 2) Arabinofuranose Residues of Lipoarabinomannan.The Mycobacterial Cell Wall--Peptidoglycan and Arabinogalactan.Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis.Erratum: Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus.Identification of a terminal rhamnopyranosyltransferase (RptA) involved in Corynebacterium glutamicum cell wall biosynthesis.Elucidation of a protein-protein interaction network involved in Corynebacterium glutamicum cell wall biosynthesis as determined by bacterial two-hybrid analysis.Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits L-glutamate efflux of Corynebacterium glutamicum.Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum.Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells.Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains.Chemoenzymatic synthesis of feruloyl D-arabinose as a potential anti-mycobacterial agent.The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 KinasesIdentification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approachIdentification of a Novel Arabinofuranosyltransferase AftB Involved in a Terminal Step of Cell Wall Arabinan Biosynthesis in Corynebacterianeae, such asCorynebacterium glutamicumandMycobacterium tuberculosisArabinan-deficient mutants of Corynebacterium glutamicum and the consequent flux in decaprenylmonophosphoryl-d-arabinose metabolismCrystal structure of the TreS-Pep2 complex, initiating α-glucan synthesis in the GlgE pathway of mycobacteriaThe singular Emb arabinofuranosyltransferase polymerises the α(1 → 5) arabinan backbone in the early stages of cell wall arabinan biosynthesisUtilisation of the Prestwick Chemical Library to identify drugs that inhibit the growth of mycobacteria
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Luke J Alderwick
@ast
Luke J Alderwick
@en
Luke J Alderwick
@es
Luke J Alderwick
@nl
type
label
Luke J Alderwick
@ast
Luke J Alderwick
@en
Luke J Alderwick
@es
Luke J Alderwick
@nl
prefLabel
Luke J Alderwick
@ast
Luke J Alderwick
@en
Luke J Alderwick
@es
Luke J Alderwick
@nl
P106
P21
P31
P496
0000-0002-1257-6053