Structural properties of CYP2D6: requirements for substrates and inhibitors

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Structural properties of CYP2D6: requirements for substrates and inhibitors

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wetenschappelijk artikel

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наукова стаття, опублікована в лютому 2014

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Structural properties of CYP2D6: requirements for substrates and inhibitors

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Structural properties of CYP2D6: requirements for substrates and inhibitors

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Structural properties of CYP2D6: requirements for substrates and inhibitors

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Structural properties of CYP2D6: requirements for substrates and inhibitors

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Structural properties of CYP2D6: requirements for substrates and inhibitors

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Structural properties of CYP2D6: requirements for substrates and inhibitors

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P1476

Structural properties of CYP2D6: requirements for substrates and inhibitors

@en

P2860

Crystal structure of human cytochrome P450 2D6

Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound

Impact of plasticity and flexibility on docking results for cytochrome P450 2D6: a combined approach of molecular dynamics and ligand docking.

Cytochromes P450 and metabolism of xenobiotics.

Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals.

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.

Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions

Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

Flexibility of human cytochrome P450 enzymes: molecular dynamics and spectroscopy reveal important function-related variations.

P304

68-78

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P31

scholarly article

P356

10.2217/FMEB2013.13.91

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P50

P577

2014-02-01T00:00:00Z

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