about
5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice.Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair.Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1.High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.Inhibition of PARP1-dependent end-joining contributes to Olaparib-mediated radiosensitization in tumor cells.Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness.The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining.DNA Repair.BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy.Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer.5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor CellsInterplay between Epigenetics, Expression of Estrogen Receptor- α, HER2/ERBB2 and Sensitivity of Triple Negative Breast Cancer Cells to Hormonal TherapyA functional ex vivo assay to detect PARP1-EJ repair and radiosensitization by PARP-inhibitor in prostate cancer.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Wael Y Mansour
@ast
Wael Y Mansour
@en
Wael Y Mansour
@es
Wael Y Mansour
@nl
type
label
Wael Y Mansour
@ast
Wael Y Mansour
@en
Wael Y Mansour
@es
Wael Y Mansour
@nl
prefLabel
Wael Y Mansour
@ast
Wael Y Mansour
@en
Wael Y Mansour
@es
Wael Y Mansour
@nl
P214
P106
P214
P31
P496
0000-0003-0641-2885
P7859
viaf-101143659