Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model

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Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model

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im November 2011 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 01 November 2011

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wetenschappelijk artikel

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наукова стаття, опублікована в листопаді 2011

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Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model

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Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model

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Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model

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Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model

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Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model

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Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model

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Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model

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Annelise Soulier

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Chun Jing Wang

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Emily M Schmidt

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Jayne L Chamberlain

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Louise E Clough

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Lukasz Wardzinski

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Rupert Kenefeck

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Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

Cellular requirements for diabetes induction in DO11.10xRIPmOVA mice.

CTLA4 gene polymorphism and autoimmunity.

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946-950

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scholarly article

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10.1002/DMRR.1277

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English

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2011-11-01T00:00:00Z

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22069290

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