How the T Cell Repertoire Becomes Peptide and MHC Specific
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Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for AllotransplantationIndoctrinating T cells to attack pathogens through homeschoolingLigand mobility modulates immunological synapse formation and T cell activationAntigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medullaAmino Acid Similarity Accounts for T Cell Cross-Reactivity and for “Holes” in the T Cell RepertoireStructural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC MoleculesHow a T Cell Receptor-like Antibody Recognizes Major Histocompatibility Complex-bound PeptideConformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificityA highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHCStructural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-EA Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR ConformersT-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergyT Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility ComplexA Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility LigandsCrossreactivity of a human autoimmune TCR is dominated by a single TCR loopEffect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand SpecificityWhat Is Direct Allorecognition?T-cell receptor gene therapy--ready to go viral?Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selectionαβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificitiesMHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selectionReconciling views on T cell receptor germline bias for MHCT cells and their eons-old obsession with MHCThe molecular basis of TCR germline bias for MHC is surprisingly simpleThymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gammaA second TCRδ locus in Galliformes uses antibody-like V domains: insight into the evolution of TCRδ and TCRμ genes in tetrapodsSeasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian InfluenzaAvian and Human Seasonal Influenza Hemagglutinin Proteins Elicit CD4 T Cell Responses That Are Comparable in Epitope Abundance and DiversityDirected evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands.The effect of mutations on the alloreactive T cell receptor/peptide-MHC interface structure: a molecular dynamics study.A translatable molecular approach to determining CD8 T-cell epitopes in TMEV infectionThe Goldilocks model for TCR-too much attraction might not be best for vaccine designStructural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.Helicobacter pylori induced gastric immunopathology is associated with distinct microbiota changes in the large intestines of long-term infected Mongolian gerbilsPeptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.Fast on-rates allow short dwell time ligands to activate T cells.An in depth analysis of the concept of "polyspecificity" assumed to characterize TCR/BCR recognitionThe ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.
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How the T Cell Repertoire Becomes Peptide and MHC Specific
description
article
@en
im Juli 2005 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в липні 2005
@uk
name
How the T Cell Repertoire Becomes Peptide and MHC Specific
@en
How the T Cell Repertoire Becomes Peptide and MHC Specific
@nl
type
label
How the T Cell Repertoire Becomes Peptide and MHC Specific
@en
How the T Cell Repertoire Becomes Peptide and MHC Specific
@nl
prefLabel
How the T Cell Repertoire Becomes Peptide and MHC Specific
@en
How the T Cell Repertoire Becomes Peptide and MHC Specific
@nl
P2093
P50
P1433
P1476
How the T Cell Repertoire Becomes Peptide and MHC Specific
@en
P2093
Clemencia Pinilla
Dean Becker
Eric S. Huseby
Frances Crawford
Tibor Vass
P304
P356
10.1016/J.CELL.2005.05.013
P407
P577
2005-07-01T00:00:00Z