about
Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation.NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal deathBHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: Possible relationship with mitochondrial membrane potentialProteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemiaNa+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memoryAntithrombin reduces ischemic volume, ameliorates neurologic deficits, and prolongs animal survival in both transient and permanent focal ischemia.GDNF selectively induces microglial activation and neuronal survival in CA1/CA3 hippocampal regions exposed to NMDA insult through Ret/ERK signalling.Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for neuroprotection.Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway.Pure uptake blockers of dopamine can reduce prolactin secretion: studies with diclofensine.Modulation of ion channels by reactive oxygen and nitrogen species: a pathophysiological role in brain aging?Histamine receptors and antihistamines: from discovery to clinical applications.MicroRNA-103-1 selectively downregulates brain NCX1 and its inhibition by anti-miRNA ameliorates stroke damage and neurological deficits.Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives.ncx1, ncx2, and ncx3 gene product expression and function in neuronal anoxia and brain ischemia.Neuroprotective, immunosuppressant and antineoplastic properties of mTOR inhibitors: current and emerging therapeutic options.Novel Cellular Mechanisms for Neuroprotection in Ischemic Preconditioning: A View from Inside Organelles.Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic braNCX1 Exchanger Cooperates with Calretinin to Confer Preconditioning-Induced Tolerance Against Cerebral Ischemia in the Striatum.A new cell-penetrating peptide that blocks the autoinhibitory XIP domain of NCX1 and enhances antiporter activity.The isolectin IB4 binds RET receptor tyrosine kinase in microglia.NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.Zn(2+) slows down Ca(V)3.3 gating kinetics: implications for thalamocortical activity.Galactosyl derivatives of L-arginine and D-arginine: synthesis, stability, cell permeation, and nitric oxide production in pituitary GH3 cells.Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism.Cu,Zn superoxide dismutase increases intracellular calcium levels via a phospholipase C-protein kinase C pathway in SK-N-BE neuroblastoma cells.TSH/cAMP up-regulate sarco/endoplasmic reticulum Ca2+-ATPases expression and activity in PC Cl3 thyroid cells.Involvement of PI3'-K, mitogen-activated protein kinase and protein kinase B in the up-regulation of the expression of nNOSalpha and nNOSbeta splicing variants induced by PRL-receptor activation in GH3 cells.Ca(2+)-independent caspase-3 but not Ca(2+)-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis.In the neuronal cell line SH-SY5Y, oxidative stress-induced free radical overproduction causes cell death without any participation of intracellular Ca(2+) increase.Evidence for a differential interaction of buprenorphine with opiate receptor subtypes controlling prolactin secretion.The NCX3 isoform of the Na+/Ca2+ exchanger contributes to neuroprotection elicited by ischemic postconditioning.Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype.Expression pattern of the ether-a-gogo-related (ERG) K+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system.Release of endogenous dopamine from tuberoinfundibular neurons.ERK1/2, p38, and JNK regulate the expression and the activity of the three isoforms of the Na+ /Ca2+ exchanger, NCX1, NCX2, and NCX3, in neuronal PC12 cells.Atypical gating of M-type potassium channels conferred by mutations in uncharged residues in the S4 region of KCNQ2 causing benign familial neonatal convulsions.Alcohol increases spontaneous BOLD signal fluctuations in the visual network.NCX1 expression and functional activity increase in microglia invading the infarct core.NCX1 is a new rest target gene: role in cerebral ischemia.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Lucio Annunziato
@ast
Lucio Annunziato
@en
Lucio Annunziato
@es
Lucio Annunziato
@nl
type
label
Lucio Annunziato
@ast
Lucio Annunziato
@en
Lucio Annunziato
@es
Lucio Annunziato
@nl
prefLabel
Lucio Annunziato
@ast
Lucio Annunziato
@en
Lucio Annunziato
@es
Lucio Annunziato
@nl
P106
P1153
7005701507
P21
P31
P496
0000-0002-8534-8270