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Effect of ligand binding on human D-amino acid oxidase: implications for the development of new drugs for schizophrenia treatmentPhysiological functions of D-amino acid oxidases: from yeast to humansModulating D-amino acid oxidase substrate specificity: production of an enzyme for analytical determination of all D-amino acids by directed evolution.Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patientsMetabolism of the neuromodulator D-serine.D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy.Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus.Structure-function relationships in human D-amino acid oxidase.D-Serine metabolism: new insights into the modulation of D-amino acid oxidase activity.Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs.The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging.High-Throughput Screening Strategy Identifies Allosteric, Covalent Human D-Amino Acid Oxidase Inhibitor.Engineering the substrate specificity of D-amino-acid oxidase.Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: a comparison between proteins from different sources.On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335.A biosensor for all D-amino acids using evolved D-amino acid oxidase.Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E. coli.Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity.Is rat an appropriate animal model to study the involvement of D-serine catabolism in schizophrenia? Insights from characterization of D-amino acid oxidase.Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex.Expression in Escherichia coli and in vitro refolding of the human protein pLG72.DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia.Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificityTHE FRESHWATER CYANOBACTERIUM PLANKTOTHRIX SP. FP1: MOLECULAR IDENTIFICATION AND DETECTION OF PARALYTIC SHELLFISH POISONING TOXINSMetabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomersThe levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson's disease patients
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description
researcher ORCID: 0000-0002-2338-2561
@en
name
Silvia Sacchi
@ast
Silvia Sacchi
@en
Silvia Sacchi
@es
Silvia Sacchi
@nl
type
label
Silvia Sacchi
@ast
Silvia Sacchi
@en
Silvia Sacchi
@es
Silvia Sacchi
@nl
prefLabel
Silvia Sacchi
@ast
Silvia Sacchi
@en
Silvia Sacchi
@es
Silvia Sacchi
@nl
P106
P1153
7004785784
P21
P31
P496
0000-0002-2338-2561