about
NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functionsCathepsin-L can resist lysis by human serum in Trypanosoma brucei bruceiModulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African TrypanosomesGenome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.Genetic dissection of drug resistance in trypanosomesDNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes.Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdAGenome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes.Trypanosomatid histones.Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis.Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes.Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.DNA breaks as triggers for antigenic variation in African trypanosomes.Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes.Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control.Subverting lysosomal function in Trypanosoma brucei.Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy.Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei.High-throughput decoding of antitrypanosomal drug efficacy and resistance.Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma bruceiRNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei.A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation.Multiplex analysis of RNA interference defects in Trypanosoma brucei.Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects.Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest.Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei.Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs.Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei.Correction: Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes.Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1.Insights into antitrypanosomal drug mode-of-action from cytology-based profilingA fluorescence in situ hybridisation study of the regulation of histone mRNA levels during the cell cycle of Trypanosoma bruceiNicotinic acetylcholine receptors on the surface of the blood fluke SchistosomaSegregation of minichromosomes in trypanosomes: implications for mitotic mechanismsChemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Sam Alsford
@ast
Sam Alsford
@en
Sam Alsford
@es
Sam Alsford
@nl
type
label
Sam Alsford
@ast
Sam Alsford
@en
Sam Alsford
@es
Sam Alsford
@nl
prefLabel
Sam Alsford
@ast
Sam Alsford
@en
Sam Alsford
@es
Sam Alsford
@nl
P106
P1153
6505963776
P31
P496
0000-0001-8621-4920