about
The free yeast aspartyl-tRNA synthetase differs from the tRNA(Asp)-complexed enzyme by structural changes in the catalytic site, hinge region, and anticodon-binding domaintRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates bindingCrystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding siteEvidence for assembly-dependent folding of protein and RNA in an icosahedral virusCrystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assemblyFunctional insights from structures of coactivator-associated arginine methyltransferase 1 domainsStructural basis for group A trichothiodystrophyNoncanonical Tandem SH2 Enables Interaction of Elongation Factor Spt6 with RNA Polymerase IIThe structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26On the Structure and Function of the Phytoene Desaturase CRTI from Pantoea ananatis, a Membrane-Peripheral and FAD-Dependent Oxidase/IsomeraseStructural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteinsStructural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoniMolecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoniStructural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active siteStructure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modificationFunctional insights from high resolution structures of mouse protein arginine methyltransferase 6The structure of Staphylococcus aureus epidermolytic toxin A, an atypic serine protease, at 1.7 A resolutionTCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xLTranslationally controlled tumor protein is a target of tumor reversionStructural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.Active site mapping of yeast aspartyl-tRNA synthetase by in vivo selection of enzyme mutations lethal for cell growth.Mutation and evolution of the magnesium-binding site of a class II aminoacyl-tRNA synthetase.Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.Cloning, expression, purification and preliminary X-ray crystallographic analysis of mouse protein arginine methyltransferase 7.Structural insights into transcription complexes.Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.Expression, purification, crystallization and preliminary crystallographic study of isolated modules of the mouse coactivator-associated arginine methyltransferase 1.Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis.Conformational flexibility of tRNA: structural changes in yeast tRNA(Asp) upon binding to aspartyl-tRNA synthetase.Cloning, purification and crystallization of a Walker-type Pyrococcus abyssi ATPase family member.Crystallization and preliminary X-ray crystallographic study of the wild type and two mutants of the CP1 hydrolytic domain from Aquifex aeolicus leucyl-tRNA synthetase.SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study.The 2.8 A structure of a T = 4 animal virus and its implications for membrane translocation of RNA.Electrostatic potential in aminoacylation by aspartyl-tRNAs synthetase.Expression, purification, and characterization of a new heterotetramer structure of leucyl-tRNA synthetase from Aquifex aeolicus in Escherichia coli.Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitorsYeast tRNAAsp recognition by its cognate class II aminoacyl-tRNA synthetaseA high resolution diffracting crystal form of the complex between yeast tRNAAsp and aspartyl-tRNA synthetase
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Jean Cavarelli
@ast
Jean Cavarelli
@en
Jean Cavarelli
@es
Jean Cavarelli
@nl
type
label
Jean Cavarelli
@ast
Jean Cavarelli
@en
Jean Cavarelli
@es
Jean Cavarelli
@nl
prefLabel
Jean Cavarelli
@ast
Jean Cavarelli
@en
Jean Cavarelli
@es
Jean Cavarelli
@nl
P106
P31
P496
0000-0001-8620-8723