The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction

The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction

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http://www.wikidata.org/entity/Q57006767
Activated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated ProteinsOligomerization and nanocluster organization render specificity.Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.Inhibition of prenylated KRAS in a lipid environmentOncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.Plasma membrane regulates Ras signaling networks.Regulation of H-Ras-driven MAPK signaling, transformation and tumorigenesis, but not PI3K signaling and tumor progression, by plasma membrane microdomains.The efficacy of Raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer-specific nanoclustering.Membrane orientation dynamics of lipid-modified small GTPases.RAS Proteins and Their Regulators in Human Disease.Regulation of K-Ras4B Membrane Binding by Calmodulin.The Ras G Domain Lacks the Intrinsic Propensity to Form Dimers.Aggregation of lipid-anchored full-length H-Ras in lipid bilayers: simulations with the MARTINI force field.A "Tug of War" Maintains a Dynamic Protein-Membrane Complex: Molecular Dynamics Simulations of C-Raf RBD-CRD Bound to K-Ras4B at an Anionic Membrane.Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain.Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: Fats on the Gunpoint
P2860

The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction

Item
http://www.wikidata.org/entity/Q57006767
description
article
@en
im August 2012 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в серпні 2012
@uk
name
The role of G-domain orientati ...... -specific membrane interaction
@en
The role of G-domain orientati ...... -specific membrane interaction
@nl
type
label
The role of G-domain orientati ...... -specific membrane interaction
@en
The role of G-domain orientati ...... -specific membrane interaction
@nl
prefLabel
The role of G-domain orientati ...... -specific membrane interaction
@en
The role of G-domain orientati ...... -specific membrane interaction
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P698
P356
P1433
P1476
The role of G-domain orientati ...... -specific membrane interaction
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P698