Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia
about
Structural polymorphism in the N-terminal oligomerization domain of NPM1Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia.A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment.Down-regulated expression of NPM1 in IMS-M2 cell line by (-)-epigallocatechin-3-gallateProteomics profiling of CLL versus healthy B-cells identifies putative therapeutic targets and a subtype-independent signature of spliceosome dysregulation.NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components.
P2860
Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia
description
article
@en
im Februar 2010 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в лютому 2010
@uk
name
Ribosome-associated nucleophos ...... chronic lymphocytic leukaemia
@en
Ribosome-associated nucleophos ...... chronic lymphocytic leukaemia
@nl
type
label
Ribosome-associated nucleophos ...... chronic lymphocytic leukaemia
@en
Ribosome-associated nucleophos ...... chronic lymphocytic leukaemia
@nl
prefLabel
Ribosome-associated nucleophos ...... chronic lymphocytic leukaemia
@en
Ribosome-associated nucleophos ...... chronic lymphocytic leukaemia
@nl
P2093
P50
P1476
Ribosome-associated nucleophos ...... chronic lymphocytic leukaemia
@en
P2093
Andrew Pettitt
Ann-Marie Buckle
Claire V Hutchinson
David Y Mason
John Burthem
Julie Adams
Karen Pulford
Karen S Rees-Unwin
Philip J Brown
P304
P356
10.1111/J.1365-2141.2009.07979.X
P407
P577
2009-11-23T00:00:00Z