about
A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndromeRegiocontrolled synthesis of the antitumor antibiotic AT2433-A1.Indolocarbazole glycosides in inactive conformations.SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/β-catenin/Id2 axis.Discovery and development of small molecule SHIP phosphatase modulators.SHIPi Enhances Autologous and Allogeneic Hematolymphoid Stem Cell Transplantation.Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancerSynthesis and initial evaluation of quinoline-based inhibitors of the SH2-containing inositol 5'-phosphatase (SHIP).Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation.Formation of DPM ethers using O-diphenylmethyl trichloroacetimidate under thermal conditions.Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.Rearrangement of Benzylic Trichloroacetimidates to Benzylic Trichloroacetamides.Alkylation of Sulfonamides with Trichloroacetimidates under Thermal ConditionsLewis Acid Catalyzed Displacement of Trichloroacetimidates in the Synthesis of Functionalized Pyrroloindolines.Preparation and Applications of 4-Methoxybenzyl Esters in Organic SynthesisImpaired T-cell survival promotes mucosal inflammatory disease in SHIP1-deficient mice.Conformational Control in the Rebeccamycin Class of Indolocarbazole Glycosides.Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival.Synthesis of N-Substituted 3-Amino-4-halopyridines: A Sequential Boc-Removal/Reductive Amination Mediated by Brønsted and Lewis Acids.Synthesis of 3,3'-Disubstituted Indolenines Utilizing the Lewis Acid Catalyzed Alkylation of 2,3-Disubstituted Indoles with Trichloroacetimidates.Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi.Synthesis of 1,1'-Diarylethanes and Related Systems by Displacement of Trichloroacetimidates with Trimethylaluminum.A multisubstrate reductase from Plantago major: structure-function in the short chain reductase superfamilyTargeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to InfectionAn acid-catalyzed macrolactonization protocolTandem oxidation/halogenation of aryl allylic alcohols under Moffatt-Swern conditionsRhodium-catalyzed addition of alkynes to activated ketones and aldehydesPalladium-catalyzed addition of alkynes to cyclopropenesBrønsted acid catalyzed monoalkylation of anilines with trichloroacetimidatesPromoter free allylation of trichloroacetimidates with allyltributylstannanes under thermal conditions to access the common 1,1'-diarylbutyl pharmacophoreMicroRNA-155 promotes G-CSF-induced mobilization of murine hematopoietic stem and progenitor cells via propagation of CXCL12 signalingThe Next Generation of Immunotherapy for Cancer: Small Molecules Could Make Big WavesDialkylation of Indoles with Trichloroacetimidates to Access 3,3-Disubstituted IndoleninesEster Formation via Symbiotic Activation Utilizing Trichloroacetimidate ElectrophilesFriedel-Crafts Alkylation of Indoles with TrichloroacetimidatesAn overview of ghrelin O-acyltransferase inhibitors: a literature and patent review for 2010-2019
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
John D Chisholm
@ast
John D Chisholm
@en
John D Chisholm
@es
John D Chisholm
@nl
type
label
John D Chisholm
@ast
John D Chisholm
@en
John D Chisholm
@es
John D Chisholm
@nl
prefLabel
John D Chisholm
@ast
John D Chisholm
@en
John D Chisholm
@es
John D Chisholm
@nl
P106
P1153
7102693152
P31
P496
0000-0001-9518-2393