about
High Efficacy but Low Potency of δ-Opioid Receptor-G Protein Coupling in Brij-58-Treated, Low-Density Plasma Membrane Fragments.Lithium - therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms.High- and low-affinity sites for sodium in δ-OR-Gi1α (Cys (351)-Ile (351)) fusion protein stably expressed in HEK293 cells; functional significance and correlation with biophysical state of plasma membrane.Plasma membrane cholesterol level and agonist-induced internalization of δ-opioid receptors; colocalization study with intracellular membrane markers of Rab family.Proteomic analysis of protein composition of rat forebrain cortex exposed to morphine for 10days; comparison with animals exposed to morphine and subsequently nurtured for 20days in the absence of this drug.Effect of therapeutic concentration of lithium on live HEK293 cells; increase of Na+/K+-ATPase, change of overall protein composition and alteration of surface layer of plasma membrane.Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal.Induction of oxidative stress by long-term treatment of live HEK293 cells with therapeutic concentration of lithium is associated with down-regulation of δ-opioid receptor amount and functionNa+/K+-ATPase level and products of lipid peroxidation in live cells treated with therapeutic lithium for different periods in time (1, 7, and 28 days); studies of Jurkat and HEK293 cellsConcurrent Compression of Phospholipid Membranes by Calcium and Cholesterol
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Miroslava Vosahlikova
@ast
Miroslava Vosahlikova
@en
Miroslava Vosahlikova
@es
Miroslava Vosahlikova
@nl
type
label
Miroslava Vosahlikova
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Miroslava Vosahlikova
@en
Miroslava Vosahlikova
@es
Miroslava Vosahlikova
@nl
prefLabel
Miroslava Vosahlikova
@ast
Miroslava Vosahlikova
@en
Miroslava Vosahlikova
@es
Miroslava Vosahlikova
@nl
P106
P31
P496
0000-0003-4832-7953