The CBM-opathies-A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex

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The CBM-opathies-A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex

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scientific article published on 19 September 2018

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wetenschappelijk artikel

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наукова стаття, опублікована у 2018

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The CBM-opathies-A Rapidly Exp ...... the CARD11-BCL10-MALT1 Complex

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The CBM-opathies-A Rapidly Exp ...... the CARD11-BCL10-MALT1 Complex

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The CBM-opathies-A Rapidly Exp ...... the CARD11-BCL10-MALT1 Complex

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The CBM-opathies-A Rapidly Exp ...... the CARD11-BCL10-MALT1 Complex

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The CBM-opathies-A Rapidly Exp ...... the CARD11-BCL10-MALT1 Complex

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The CBM-opathies-A Rapidly Exp ...... the CARD11-BCL10-MALT1 Complex

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The CBM-opathies-A Rapidly Exp ...... the CARD11-BCL10-MALT1 Complex

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P2093

Andrew L Snow

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Batsukh Dorjbal

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Joshua D Milner

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Swadhinya Arjunaraja

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Creative Commons Attribution 4.0 International

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c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB

A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue

CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B

Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B

CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B

Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation

Phosphorylation of the CARMA1 linker controls NF-kappaB activation

Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

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2078

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scholarly article

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10.3389/FIMMU.2018.02078

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English

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Stuart E Turvey

Henry Y Lu

Bradly M Bauman

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2018-09-19T00:00:00Z

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30283440

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severe combined immunodeficiency

peptide

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6156466

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