about
Catalytic competence of the Ras-GEF domain of hSos1 requires intra-REM domain interactions mediated by phenylalanine 577The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domainWhi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate.Subcellular localization of the cyclin dependent kinase inhibitor Sic1 is modulated by the carbon source in budding yeast.Proteomic analysis of a nutritional shift-up in Saccharomyces cerevisiae identifies Gvp36 as a BAR-containing protein involved in vesicular traffic and nutritional adaptation.An acidic loop and cognate phosphorylation sites define a molecular switch that modulates ubiquitin charging activity in Cdc34-like enzymesA comparative study of Whi5 and retinoblastoma proteins: from sequence and structure analysis to intracellular networks.Mutations of the CK2 phosphorylation site of Sic1 affect cell size and S-Cdk kinase activity in Saccharomyces cerevisiae.Sic1 is phosphorylated by CK2 on Ser201 in budding yeast cells.Cell size at S phase initiation: an emergent property of the G1/S network.Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts.First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand.Data recovery and integration from public databases uncovers transformation-specific transcriptional downregulation of cAMP-PKA pathway-encoding genes.Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation.The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin.Control of the yeast cell cycle by protein synthesis.In CK2 inactivated cells the cyclin dependent kinase inhibitor Sic1 is involved in cell-cycle arrest before the onset of S phase.Computational strategies for a system-level understanding of metabolism.Conglutin gamma, a lupin seed protein, binds insulin in vitro and reduces plasma glucose levels of hyperglycemic rats.Glucose modulation of cell size in yeast.Acquired glucose sensitivity of k-ras transformed fibroblasts.K-Ras Activation Induces Differential Sensitivity to Sulfur Amino Acid Limitation and Deprivation and to Oxidative and Anti-Oxidative Stress in Mouse FibroblastsCancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodelingStructural heterogeneity in populations of the budding yeast Saccharomyces cerevisiae5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits.RAS and PKA pathways in cancer: new insight from transcriptional analysis.Order propensity of an intrinsically disordered protein, the cyclin-dependent-kinase inhibitor Sic1Comparative analysis of the molecular mechanisms controlling the initiation of chromosomal DNA replication in yeast and in mammalian cells.Glucose signaling-mediated coordination of cell growth and cell cycle in Saccharomyces cerevisiae.Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007--present).A systems biology road map for the discovery of drugs targeting cancer cell metabolism.PO-12 - The key role of talin-1 in cancer cell extravasation dissected through human vascularized 3D microfluidic model.Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells.Respiratory metabolism and calorie restriction relieve persistent endoplasmic reticulum stress induced by calcium shortage in yeast.Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-Ras(G13D).The isolated catalytic hairpin of the Ras-specific guanine nucleotide exchange factor Cdc25Mm retains nucleotide dissociation activity but has impaired nucleotide exchange activity.A dominant negative RAS-specific guanine nucleotide exchange factor reverses neoplastic phenotype in K-ras transformed mouse fibroblasts.Characterization and properties of dominant-negative mutants of the ras-specific guanine nucleotide exchange factor CDC25(Mm).Molecular dynamics simulation of the interaction between the complex iron-sulfur flavoprotein glutamate synthase and its substrates.A cell sizer network involving Cln3 and Far1 controls entrance into S phase in the mitotic cycle of budding yeast.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Marco Vanoni
@ast
Marco Vanoni
@en
Marco Vanoni
@es
Marco Vanoni
@nl
type
label
Marco Vanoni
@ast
Marco Vanoni
@en
Marco Vanoni
@es
Marco Vanoni
@nl
prefLabel
Marco Vanoni
@ast
Marco Vanoni
@en
Marco Vanoni
@es
Marco Vanoni
@nl
P106
P21
P31
P496
0000-0002-8690-2587