about
The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth conesCHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complexClustering of the neural cell adhesion molecule (NCAM) at the neuronal cell surface induces caspase-8- and -3-dependent changes of the spectrin meshwork required for NCAM-mediated neurite outgrowthAβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.Immobilized pool of NCAM180 in the postsynaptic membrane is homeostatically replenished by the flux of NCAM180 from extrasynaptic regions.Trans-Golgi network delivery of synaptic proteins in synaptogenesis.NCAM promotes assembly and activity-dependent remodeling of the postsynaptic signaling complex.RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation.Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth.Neural cell adhesion molecule (NCAM) association with PKCbeta2 via betaI spectrin is implicated in NCAM-mediated neurite outgrowth.NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.Cell adhesion and intracellular calcium signaling in neurons.L1CAM increases MAP2 expression via the MAPK pathway to promote neurite outgrowth.Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth.The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1).Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels.The adhesion molecule CHL1 regulates uncoating of clathrin-coated synaptic vesicles.PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes.Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene.The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent mechanisms.Glial Scar Expression of CHL1, the Close Homolog of the Adhesion Molecule L1, Limits Recovery after Spinal Cord Injury
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Iryna Leshchyns'ka
@ast
Iryna Leshchyns'ka
@en
Iryna Leshchyns'ka
@es
Iryna Leshchyns'ka
@nl
type
label
Iryna Leshchyns'ka
@ast
Iryna Leshchyns'ka
@en
Iryna Leshchyns'ka
@es
Iryna Leshchyns'ka
@nl
altLabel
Iryna Leshchyns'ka
@en
prefLabel
Iryna Leshchyns'ka
@ast
Iryna Leshchyns'ka
@en
Iryna Leshchyns'ka
@es
Iryna Leshchyns'ka
@nl
P106
P1153
6507222837
P31
P496
0000-0002-2025-5831