Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone

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Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone

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im Juni 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 05 June 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в червні 2018

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name

Human Cytochrome CYP17A1: The ...... ty with 17-Hydroxyprogesterone

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Human Cytochrome CYP17A1: The ...... ty with 17-Hydroxyprogesterone

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label

Human Cytochrome CYP17A1: The ...... ty with 17-Hydroxyprogesterone

@en

Human Cytochrome CYP17A1: The ...... ty with 17-Hydroxyprogesterone

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prefLabel

Human Cytochrome CYP17A1: The ...... ty with 17-Hydroxyprogesterone

@en

Human Cytochrome CYP17A1: The ...... ty with 17-Hydroxyprogesterone

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P1476

Human Cytochrome CYP17A1: The ...... ty with 17-Hydroxyprogesterone

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P2093

Ilia G Denisov

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Michael C Gregory

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Piotr J Mak

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Ruchia Duggal

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Stephen G Sligar

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P2860

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

Alteration of P450 distal pocket solvent leads to impaired proton delivery and changes in heme geometry

Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect

Structures of human steroidogenic cytochrome P450 17A1 with substrates

Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps.

CYP17 inhibitors--abiraterone, C17,20-lyase inhibitors and multi-targeting agents.

CYP17A1 inhibitors in castration-resistant prostate cancer

Simultaneous observation of the O---O and Fe---O2 stretching modes in oxyhemoglobins

Resonance Raman characterization of the peroxo and hydroperoxo intermediates in cytochrome P450.

Temperature derivative spectroscopy to monitor the autoxidation decay of cytochromes P450

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7324-7331

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P31

scholarly article

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10.1021/JACS.8B03901

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English

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140

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James R Kincaid

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2018-06-05T00:00:00Z

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29758981

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catalysis

general chemistry

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5999583

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