Prevalent and Low-Frequency Null Mutations in the Filaggrin Gene Are Associated with Early-Onset and Persistent Atopic Eczema
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Twin Studies of Atopic Dermatitis: Interpretations and Applications in the Filaggrin EraSkin barrier defects in atopic dermatitisFilaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptensFilaggrin gene mutation c.3321delA is associated with various clinical features of atopic dermatitis in the Chinese Han population.Filaggrin gene defects are independent risk factors for atopic asthma in a Polish population: a study in ECAP cohortFilaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children.The infectious aspects of atopic dermatitis.Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age.Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study.Epidermal barrier in atopic dermatitis.One remarkable molecule: filaggrin.Does eczema lead to asthma?Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infantsRecent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus.Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis.Ichthyosis vulgaris: the filaggrin mutation disease.Novel FLG null mutations in Korean patients with atopic dermatitis and comparison of the mutational spectra in Asian populations.The Genetics and Epigenetics of Atopic Dermatitis-Filaggrin and Other Polymorphisms.microRNA and Allergy.Molecular mechanisms in atopic eczema: insights gained from genetic studies.Age at onset and persistence of eczema are related to subsequent risk of asthma and hay fever from birth to 18 years of age.Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations.Severe skin inflammation and filaggrin mutation similarly alter the skin barrier in patients with atopic dermatitis.Lack of association between filaggrin gene mutations and onset of psoriasis in childhood.Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts.Filaggrin compound heterozygous patients carry mutations in trans position.Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease.Hand eczema, atopic dermatitis and filaggrin mutations in adult Danes: a registry-based study assessing risk of disability pension.Impact of filaggrin mutations on Raman spectra and biophysical properties of the stratum corneum in mild to moderate atopic dermatitisIndividuals who are homozygous for the 2282del4 and R501X filaggrin null mutations do not always develop dermatitis and complete long-term remission is possible
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Prevalent and Low-Frequency Null Mutations in the Filaggrin Gene Are Associated with Early-Onset and Persistent Atopic Eczema
description
article
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im Dezember 2007 veröffentlichter wissenschaftlicher Artikel
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wetenschappelijk artikel
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наукова стаття, опублікована в червні 2008
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name
Prevalent and Low-Frequency Nu ...... t and Persistent Atopic Eczema
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Prevalent and Low-Frequency Nu ...... t and Persistent Atopic Eczema
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type
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Prevalent and Low-Frequency Nu ...... t and Persistent Atopic Eczema
@en
Prevalent and Low-Frequency Nu ...... t and Persistent Atopic Eczema
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Prevalent and Low-Frequency Nu ...... t and Persistent Atopic Eczema
@en
Prevalent and Low-Frequency Nu ...... t and Persistent Atopic Eczema
@nl
P2093
P50
P356
P1476
Prevalent and low-frequency nu ...... t and persistent atopic eczema
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P2093
Aileen Sandilands
Haihui Liao
Heather J Cordell
Simon J Meggitt
Yiwei Zhao
P2888
P304
P356
10.1038/SJ.JID.5701206
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P577
2007-12-20T00:00:00Z