Three ways in, one way out: water dynamics in the trans-membrane domains of the inner membrane translocase AcrB
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Molecular Simulations of Gram-Negative Bacterial Membranes: A Vignette of Some Recent SuccessesRecent advances toward a molecular mechanism of efflux pump inhibitionStructural basis of RND-type multidrug exportersThe mechanism of proton translocation in respiratory complex I from molecular dynamics.Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations.Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrBSubstrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB.The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosaStepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB.Aminoacyl β-naphthylamides as substrates and modulators of AcrB multidrug efflux pumpMolecular Dynamics Computer Simulations of Multidrug RND Efflux PumpsEfflux pump-mediated antibiotics resistance: insights from computational structural biology.Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters.Catalysis of GTP hydrolysis by small GTPases at atomic detail by integration of X-ray crystallography, experimental, and theoretical IR spectroscopy.Computational study of correlated domain motions in the AcrB efflux transporter.Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains.Constant pH Molecular Dynamics Reveals How Proton Release Drives the Conformational Transition of a Transmembrane Efflux Pump.Molecular Modeling of Multidrug Properties of Resistance Nodulation Division (RND) Transporters.Coarse-grained simulations of conformational changes in the multidrug efflux transporter AcrB.Energetics and conformational pathways of functional rotation in the multidrug transporter AcrB.Unidirectional peristaltic movement in multisite drug binding pockets of AcrB from molecular dynamics simulations.Application of Room-Temperature Aprotic and Protic Ionic Liquids for Oxidative Folding of Cysteine-Rich Peptides
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Three ways in, one way out: water dynamics in the trans-membrane domains of the inner membrane translocase AcrB
description
article
@en
im Oktober 2011 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в жовтні 2011
@uk
name
Three ways in, one way out: wa ...... nner membrane translocase AcrB
@en
Three ways in, one way out: wa ...... nner membrane translocase AcrB
@nl
type
label
Three ways in, one way out: wa ...... nner membrane translocase AcrB
@en
Three ways in, one way out: wa ...... nner membrane translocase AcrB
@nl
prefLabel
Three ways in, one way out: wa ...... nner membrane translocase AcrB
@en
Three ways in, one way out: wa ...... nner membrane translocase AcrB
@nl
P2860
P356
P1433
P1476
Three ways in, one way out: wa ...... nner membrane translocase AcrB
@en
P2093
Christian Kandt
Nadine Fischer
P2860
P304
P356
10.1002/PROT.23122
P407
P577
2011-10-01T00:00:00Z