about
No evidence for the in vivo activity of aromatase-inhibiting flavonoidsNovel Lignan and stilbenoid mixture shows anticarcinogenic efficacy in preclinical PC-3M-luc2 prostate cancer model.Dietary phytoestrogens and their role in hormonally dependent disease.Hydroxymatairesinol, a novel enterolactone precursor with antitumor properties from coniferous tree (Picea abies).Tamoxifen and flaxseed alter angiogenesis regulators in normal human breast tissue in vivo.Effect of dietary intervention on serum lignan levels in pregnant women - a controlled trial.Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats.Tools to evaluate estrogenic potency of dietary phytoestrogens:A consensus paper from the EU Thematic Network "Phytohealth" (QLKI-2002-2453)Can modulation of mammary gland development by dietary factors support breast cancer prevention?Role of dietary lignans in the reduction of breast cancer risk.Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products.Transcriptional response networks for elucidating mechanisms of action of multitargeted agents.Improved statistical modeling of tumor growth and treatment effect in preclinical animal studies with highly heterogeneous responses in vivo.Tamoxifen, flaxseed, and the lignan enterolactone increase stroma- and cancer cell-derived IL-1Ra and decrease tumor angiogenesis in estrogen-dependent breast cancer.Changes in biomarkers of estrogen receptor and growth factor signaling pathways in MCF-7 tumors after short- and long-term treatment with soy and flaxseed.Flaxseed and soy protein isolate, alone and in combination, differ in their effect on bone mass, biomechanical strength, and uterus in ovariectomized nude mice with MCF-7 human breast tumor xenografts.Hydroxymatairesinol and its mammalian metabolite enterolactone reduce the growth and metastasis of subcutaneous AH109A hepatomas in rats.Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity.HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo.Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model.Prolonged administration of secoisolariciresinol diglycoside increases lignan excretion and alters lignan tissue distribution in adult male and female rats.Enterolactone inhibits the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in the rat.Antioxidant and antitumor effects of hydroxymatairesinol (HM-3000, HMR), a lignan isolated from the knots of spruce.Chemopreventive effects of hydroxymatairesinol on uterine carcinogenesis in Donryu rats.Urinary excretion of lignans after administration of isolated plant lignans to rats: the effect of single dose and ten-day exposures.Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats.Hydroxymatairesinol and sesaminol act differently on tocopherol concentrations in rats.Determination of plant and enterolignans in human serum by high-performance liquid chromatography with tandem mass spectrometric detection.HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium.Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue.Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice.IL-10 suppresses TNF-α-induced expression of human aromatase gene in mammary adipose tissue.The soy effect in the disease models of nonbacterial prostatitis and obstructive voidingEstradiol, tamoxifen, and flaxseed alter IL-1β and IL-1Ra levels in normal human breast tissue in vivo
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Niina Saarinen
@ast
Niina Saarinen
@en
Niina Saarinen
@es
Niina Saarinen
@nl
type
label
Niina Saarinen
@ast
Niina Saarinen
@en
Niina Saarinen
@es
Niina Saarinen
@nl
prefLabel
Niina Saarinen
@ast
Niina Saarinen
@en
Niina Saarinen
@es
Niina Saarinen
@nl
P106
P31
P496
0000-0003-3531-378X