Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors

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Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors

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scientific article published on 23 August 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в серпні 2018

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name

Targeting IKKβ in Cancer: Chal ...... Utilisation of IKKβ Inhibitors

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Targeting IKKβ in Cancer: Chal ...... Utilisation of IKKβ Inhibitors

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Item

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Targeting IKKβ in Cancer: Chal ...... Utilisation of IKKβ Inhibitors

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Targeting IKKβ in Cancer: Chal ...... Utilisation of IKKβ Inhibitors

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Targeting IKKβ in Cancer: Chal ...... Utilisation of IKKβ Inhibitors

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Targeting IKKβ in Cancer: Chal ...... Utilisation of IKKβ Inhibitors

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P1476

Targeting IKKβ in Cancer: Chal ...... Utilisation of IKKβ Inhibitors

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P2093

Jack A Prescott

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Hallmarks of Cancer: The Next Generation

Binding of manumycin A inhibits IkappaB kinase beta activity

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers

Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

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115

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scholarly article

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10.3390/CELLS7090115

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English

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P478

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Simon J Cook

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2018-08-23T00:00:00Z

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30142927

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6162708

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