ONC201 demonstrates anti-tumorigenic and anti-metastatic activity in uterine serous carcinoma in vitro

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ONC201 demonstrates anti-tumorigenic and anti-metastatic activity in uterine serous carcinoma in vitro

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wetenschappelijk artikel

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наукова стаття, опублікована у 2018

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ONC201 demonstrates anti-tumor ...... rine serous carcinoma in vitro

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ONC201 demonstrates anti-tumor ...... rine serous carcinoma in vitro

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ONC201 demonstrates anti-tumor ...... rine serous carcinoma in vitro

@en

ONC201 demonstrates anti-tumor ...... rine serous carcinoma in vitro

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ONC201 demonstrates anti-tumor ...... rine serous carcinoma in vitro

@en

ONC201 demonstrates anti-tumor ...... rine serous carcinoma in vitro

@nl

P1476

ONC201 demonstrates anti-tumor ...... rine serous carcinoma in vitro

@en

P2093

Arthur-Quan Tran

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Chunxiao Zhou

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Jiandong Wang

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Leslie H Clark

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Lindsay West

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Stephanie A Sullivan

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Stuart R Pierce

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Varun V Prabhu

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Victoria Bae-Jump

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Weimin Kong

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P2860

Trail resistance induces epithelial-mesenchymal transition and enhances invasiveness by suppressing PTEN via miR-221 in breast cancer.

Buformin exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells

Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10.

Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects.

ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies.

ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases.

Management of women with uterine papillary serous cancer: a Society of Gynecologic Oncology (SGO) review.

Discovery and clinical introduction of first-in-class imipridone ONC201.

Targeted therapy in uterine serous carcinoma: an aggressive variant of endometrial cancer.

Early stage uterine serous carcinoma: management updates and genomic advances.

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1551-1563

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scholarly article

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English

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P478

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P577

2018-01-01T00:00:00Z

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30210923

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P932

6129479

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