Structure-Activity Relationships of Pan-Gα Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators

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Structure-Activity Relationships of Pan-Gα Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators

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im Juli 2018 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована в липні 2018

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Structure-Activity Relationshi ...... Positive Allosteric Modulators

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Structure-Activity Relationshi ...... Positive Allosteric Modulators

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Structure-Activity Relationshi ...... Positive Allosteric Modulators

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Structure-Activity Relationshi ...... Positive Allosteric Modulators

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Structure-Activity Relationshi ...... Positive Allosteric Modulators

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Structure-Activity Relationshi ...... Positive Allosteric Modulators

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P1476

Structure-Activity Relationshi ...... Positive Allosteric Modulators

@en

P2093

Aaron M Bender

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Alice E Berizzi

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Arthur Christopoulos

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Christopher J Langmead

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Patrick M Sexton

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P2860

Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)

Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.

Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.

P304

1818-1828

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P31

scholarly article

P356

10.1021/ACSCHEMNEURO.8B00136

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Craig W. Lindsley

P Jeffrey Conn

P577

2018-07-18T00:00:00Z

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P698

29683647

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P921

cell biology

P932

6106869

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