about
Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activityReaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase.Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase.Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol.Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formationStereoselective oxidation of regioisomeric octadecenoic acids by fatty acid dioxygenases.A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection.Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents.Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes.BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly.Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screeningA lipoxygenase with dual positional specificity is expressed in olives (Olea europaea L.) during ripening.Effects of PCB126 and 17β-oestradiol on endothelium-derived vasoactive factors in human endothelial cells.Critical amino acids for the 8(R)-dioxygenase activity of linoleate diol synthase. A comparison with cyclooxygenases.Enantiomeric separation and analysis of unsaturated hydroperoxy fatty acids by chiral column chromatography-mass spectrometry.Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism.Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7.Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors.Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7.Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583]A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP)Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenaseSynthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP InhibitorsSteric analysis of 8-hydroxy- and 10-hydroxyoctadecadienoic acids and dihydroxyoctadecadienoic acids formed from 8R-hydroperoxyoctadecadienoic acid by hydroperoxide isomerasesManganese lipoxygenase oxidizes bis-allylic hydroperoxides and octadecenoic acids by different mechanismsPayne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometryCharacterization of the interaction of human 5-lipoxygenase with its activating protein FLAPDiscovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual ScreeningAn experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesisTargeting biosynthetic networks of the proinflammatory and proresolving lipid metabolomeExotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesisLiquid chromatography-coupled mass spectrometry analysis of glutathione conjugates of oxygenated polyunsaturated fatty acidsImpact of food polyphenols on oxylipin biosynthesis in human neutrophils
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Ulrike Garscha
@ast
Ulrike Garscha
@en
Ulrike Garscha
@es
Ulrike Garscha
@nl
type
label
Ulrike Garscha
@ast
Ulrike Garscha
@en
Ulrike Garscha
@es
Ulrike Garscha
@nl
prefLabel
Ulrike Garscha
@ast
Ulrike Garscha
@en
Ulrike Garscha
@es
Ulrike Garscha
@nl
P106
P31
P496
0000-0002-3645-7833