A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases
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The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complexCross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation siteInteraction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changesThe human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activityThe CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytesA multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5A novel human tyrosine kinase gene inducible in T cells by interleukin 2Association between mitogen-activated protein kinase and the zeta chain of the T cell receptor (TcR) with the SH2,3 domain of p56lck. Differential regulation by TcR cross-linking.Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells.Recognition of the Lck tyrosine kinase as a tumor antigen by cytotoxic T lymphocytes of cancer patients with distant metastases.Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia.High levels of heterodisperse RNAs accumulate in T cells infected with human immunodeficiency virus and in normal thymocytes.Pillars article: the CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. 1988.Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.Physical and functional association of p56lck with Fc gamma RIIIA (CD16) in natural killer cells.A conserved helix motif complements the protein kinase core.Selective expression of alternative lck mRNAs in human malignant cell lines.Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells.Structure of the murine lck gene and its rearrangement in a murine lymphoma cell lineTranscriptional activation of lck by retrovirus promoter insertion between two lymphoid-specific promoters.Two lck transcripts containing different 5' untranslated regions are present in T cells.Disturbance of nuclear transport of proteins in CD4+ cells expressing gp160 of human immunodeficiency virus.Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor functionOncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia.Accumulation of p60lck in HTLV-I-transformed T cell lines detected by an anti-lck monoclonal antibody, MOL 171.Identification of Lck-derived peptides capable of inducing HLA-A2-restricted and tumor-specific CTLs in cancer patients with distant metastases.lck suppresses gene expression from various promoters including human T-cell leukemia virus type I promoter.Mouse monoclonal antibodies that specifically recognize an amino-terminal epitope of p56lck protein tyrosine kinase.Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells
P2860
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P2860
A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases
description
im Januar 1986 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в 1986
@uk
name
A human T cell-specific cDNA c ...... ly of protein-tyrosine kinases
@en
A human T cell-specific cDNA clone
@nl
type
label
A human T cell-specific cDNA c ...... ly of protein-tyrosine kinases
@en
A human T cell-specific cDNA clone
@nl
prefLabel
A human T cell-specific cDNA c ...... ly of protein-tyrosine kinases
@en
A human T cell-specific cDNA clone
@nl
P2093
P356
P1476
A human T cell-specific cDNA c ...... ly of protein-tyrosine kinases
@en
P2093
Barry Toyonaga
Nicolette Caccia
Rosanne Spolski
Tak W. Mak
Yasuhiro Koga
Yasunobu Yoshikai
Yusuke Yanagi
P304
P356
10.1002/EJI.1830161229
P407
P577
1986-01-01T00:00:00Z