Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
about
Targeting the intragraft microenvironment and the development of chronic allograft rejectionGenetic barriers in transplantation medicineAn antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejectionAnti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantationDonor and recipient leukocytes in organ allografts of recipients with variable donor-specific tolerance: with particular reference to chronic rejectionCTLA-4 up-regulation plays a role in tolerance mediated by CD45.T-cell receptor V(alpha) usage by effector CD4+Vbeta11+ T cells mediating graft-versus-host disease directed to minor histocompatibility antigens.Tracking antigen-driven responses by flow cytometry: monitoring proliferation by dye dilution.Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells.IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells.Memory T-cell-specific therapeutics in organ transplantation.Homeostatic proliferation is a barrier to transplantation tolerance.Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome.Immunoregulatory functions of mTOR inhibition.Transplantation tolerance-where do we stand?Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates.High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease.Bim regulates alloimmune-mediated vascular injury through effects on T-cell activation and death.High-dose, post-transplantation cyclophosphamide to promote graft-host tolerance after allogeneic hematopoietic stem cell transplantationFragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory.Requirements for induction and maintenance of peripheral tolerance in stringent allograft modelsIn vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response.Immunosuppression for lung transplantation.The tolerant recipient: looking great in someone else's genes.The role of T helper cell differentiation in promoting nerve allograft survival with costimulation blockademTOR inhibitors: an overview.Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion.Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cellsPrevention of airway allograft tolerance by polyinosinic:polycytidylic acid requires type I interferon responsiveness for mouse airway obliterationIs transplantation tolerable?Challenges to achieving clinical transplantation tolerance.Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors.GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppressionRequirement for natural killer T (NKT) cells in the induction of allograft toleranceTresperimus: a new agent for transplant tolerance induction.Creating transplant tolerance by taming adverse intragraft innate immunity.Spontaneous acceptance of liver transplants in rodents: evidence that liver leucocytes induce recipient T-cell death by neglect.CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival.Dendritic cells, tolerance induction and transplant outcome.Novel therapeutics for the treatment of graft-versus-host disease.
P2860
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P2860
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
description
im November 1999 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в листопаді 1999
@uk
name
Blocking both signal 1 and sig ...... peripheral allograft tolerance
@en
Blocking both signal 1 and sig ...... peripheral allograft tolerance
@nl
type
label
Blocking both signal 1 and sig ...... peripheral allograft tolerance
@en
Blocking both signal 1 and sig ...... peripheral allograft tolerance
@nl
prefLabel
Blocking both signal 1 and sig ...... peripheral allograft tolerance
@en
Blocking both signal 1 and sig ...... peripheral allograft tolerance
@nl
P2093
P356
P1433
P1476
Blocking both signal 1 and sig ...... peripheral allograft tolerance
@en
P2093
Andrew D. Wells
Laurence A. Turka
Terry B. Strom
Xian Chang Li
Xin Xiao Zheng
Yongsheng Li
P2888
P304
P356
10.1038/15256
P407
P577
1999-11-01T00:00:00Z