Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl)uracil derivatives

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The unabated synthesis of new nucleoside analogues with antiviral potential: a tribute to Morris J. Robins.

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Q37698440-A8BC7EB5-2763-4527-B73C-9915C35BA10C

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Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl)uracil derivatives

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http://www.wikidata.org/entity/Q57241342

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article

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im April 2006 veröffentlichter wissenschaftlicher Artikel

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наукова стаття, опублікована у квітні 2006

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Synthesis and biological evalu ...... enesulfonyl)uracil derivatives

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type

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Synthesis and biological evalu ...... enesulfonyl)uracil derivatives

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Synthesis and biological evalu ...... enesulfonyl)uracil derivatives

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Synthesis and biological evalu ...... enesulfonyl)uracil derivatives

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Erik De Clercq

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Morris J Robins

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Zlatko Janeba

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P2860

Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base

Process Research and Development of a Dihydropyrimidine Dehydrogenase Inactivator: Large-Scale Preparation of Eniluracil Using a Sonogashira Coupling

Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism.

Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication.

Highly potent and selective inhibition of varicella-zoster virus replication by bicyclic furo[2,3-d]pyrimidine nucleoside analogues.

Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.

Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase.

Fluorescent bicyclic furo pyrimidine deoxynucleoside analogs as potent and selective inhibitors of VZV and potential future drugs for the treatment of chickenpox and shingles

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580-586

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scholarly article

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10.1139/V06-041

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English

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Jan Balzarini

Robert Snoeck

Graciela Andrei

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2006-04-01T00:00:00Z

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Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl)uracil derivatives

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P2860

P2860

Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl)uracil derivatives

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P1476

P2093

P2860

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P31

P356

P407

P433

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P577

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P1433

P1476

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P2860

P304

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P356

P407

P433

P478

P50

P577