Activity of the Nurr1 Carboxyl-terminal Domain Depends on Cell Type and Integrity of the Activation Function 2
about
Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptorsThe AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurineThe constitutive and inducible expression of Nurr1, a key regulator of dopaminergic neuronal differentiation, in human neural and non-neural cell lines.PIASgamma represses the transcriptional activation induced by the nuclear receptor Nurr1.Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.PIASγ enhanced SUMO-2 modification of Nurr1 activation-function-1 domain limits Nurr1 transcriptional synergyThe N-terminal region of Nurr1 (a.a 1-31) is essential for its efficient degradation by the ubiquitin proteasome pathway.Differential regulation of human 3β-hydroxysteroid dehydrogenase type 2 for steroid hormone biosynthesis by starvation and cyclic AMP stimulation: studies in the human adrenal NCI-H295R cell model.Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cellsFGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk.The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailedMolecular fingerprinting of TGFbeta-treated embryonic maxillary mesenchymal cells.Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1.Transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage.Induction of cell cycle arrest and morphological differentiation by Nurr1 and retinoids in dopamine MN9D cells.Translated mutation in the Nurr1 gene as a cause for Parkinson's disease.The glucocorticoid receptor is a co-regulator of the orphan nuclear receptor Nurr1
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P2860
Activity of the Nurr1 Carboxyl-terminal Domain Depends on Cell Type and Integrity of the Activation Function 2
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Dezember 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 1999
@uk
name
Activity of the Nurr1 Carboxyl ...... y of the Activation Function 2
@en
Activity of the Nurr1 Carboxyl ...... y of the Activation Function 2
@nl
type
label
Activity of the Nurr1 Carboxyl ...... y of the Activation Function 2
@en
Activity of the Nurr1 Carboxyl ...... y of the Activation Function 2
@nl
prefLabel
Activity of the Nurr1 Carboxyl ...... y of the Activation Function 2
@en
Activity of the Nurr1 Carboxyl ...... y of the Activation Function 2
@nl
P2093
P2860
P356
P1476
Activity of the Nurr1 Carboxyl ...... y of the Activation Function 2
@en
P2093
Diogo S. Castro
Maria Bondesson Bolin
Mariette Arvidsson
Thomas Perlmann
P2860
P304
37483-37490
P356
10.1074/JBC.274.52.37483
P407
P577
1999-12-24T00:00:00Z