about
Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chainCytochrome c signalosome in mitochondria.Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch.Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy.Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1).Genetic modification of hypoxia signaling in animal models and its effect on cancer.The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB.Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation.Nitration of tyrosines 46 and 48 induces the specific degradation of cytochrome c upon change of the heme iron state to high-spin.Effect of nitration on the physicochemical and kinetic features of wild-type and monotyrosine mutants of human respiratory cytochrome c.Acetylsalicylic acid induces programmed cell death in Arabidopsis cell cultures.Perturbation of the redox site structure of cytochrome c variants upon tyrosine nitration.A Non-damaging Method to Analyze the Configuration and Dynamics of Nitrotyrosines in ProteinsSpecific nitration of tyrosines 46 and 48 makes cytochromecassemble a non-functional apoptosome
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
José M García-Heredia
@ast
José M García-Heredia
@en
José M García-Heredia
@es
José M García-Heredia
@nl
type
label
José M García-Heredia
@ast
José M García-Heredia
@en
José M García-Heredia
@es
José M García-Heredia
@nl
prefLabel
José M García-Heredia
@ast
José M García-Heredia
@en
José M García-Heredia
@es
José M García-Heredia
@nl
P106
P1153
14018078100
57201179056
P21
P31
P496
0000-0003-3095-0050