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Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence AgentsStaphylococcus aureus DsbA does not have a destabilizing disulfide. A new paradigm for bacterial oxidative foldingIn vivo oxidative protein folding can be facilitated by oxidation-reduction cyclingStructural and functional characterization of three DsbA paralogues from Salmonella enterica serovar TyphimuriumRv2969c, essential for optimal growth inMycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidasesStructural Insights into the Role of the Cyclic Backbone in a Squash Trypsin InhibitorComparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct ClassesThe antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumpingThe 1.2 Å resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin productionStructure of the Acinetobacter baumannii Dithiol Oxidase DsbA Bound to Elongation Factor EF-Tu Reveals a Novel Protein Interaction SiteApplication of fragment-based screening to the design of inhibitors of Escherichia coli DsbAStructural and Biochemical Characterization of Chlamydia trachomatis DsbA Reveals a Cysteine-Rich and Weakly Oxidising OxidoreductaseDehydration converts DsbG crystal diffraction from low to high resolution.Laboratory evolution of one disulfide isomerase to resemble anotherCloning, expression, purification and characterization of a DsbA-like protein from Wolbachia pipientis.Bioinformatics Tools and Resources for Analyzing Protein Structures.Cloning and functional characterization of a homoglutathione synthetase from pea nodules.Expression and crystallization of SeDsbA, SeDsbL and SeSrgA from Salmonella enterica serovar Typhimurium.Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance.The acidic nature of the CcmG redox-active center is important for cytochrome c maturation in Escherichia coli.Nuclear phosphoinositides could bring FYVE alive.Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide.Targeting virulence not viability in the search for future antibacterials.Post-crystallization treatments for improving diffraction quality of protein crystals.Crystallization and preliminary diffraction analysis of a DsbA homologue from Wolbachia pipientis.Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic ProteinDSB proteins and bacterial pathogenicity.A periplasmic thioredoxin-like protein plays a role in defense against oxidative stress in Neisseria gonorrhoeae.Autotransporter adhesins in Escherichia coli pathogenesis.Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility.New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.Unraveling the redox properties of the global regulator FurA from Anabaena sp. PCC 7120: disulfide reductase activity based on its CXXC motifs.INHIBITION OF DIVERSE DsbA ENZYMES IN MULTI-DsbA ENCODING PATHOGENS.Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis.Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonismThe atypical thiol-disulfide exchange protein α-DsbA2 from Wolbachia pipientis is a homotrimeric disulfide isomeraseUnique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromoleculesThe Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA InhibitorsStructural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogensMolecular and structural insights into an asymmetric proteolytic complex (ClpP1P2) from Mycobacterium smegmatis
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