about
The mechanisms of Fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes.Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice.Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue.Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus.Neuronal human BACE1 knockin induces systemic diabetes in mice.Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance.Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE-/- mouse model of atherosclerosis with alterations in IL10/AMPKα pathway.Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice.Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction.Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues.Methionine restriction improves renal insulin signalling in aged kidneys.Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis.Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice.Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen signaling.Regulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B.
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Nimesh Mody
@ast
Nimesh Mody
@en
Nimesh Mody
@es
Nimesh Mody
@nl
type
label
Nimesh Mody
@ast
Nimesh Mody
@en
Nimesh Mody
@es
Nimesh Mody
@nl
prefLabel
Nimesh Mody
@ast
Nimesh Mody
@en
Nimesh Mody
@es
Nimesh Mody
@nl
P106
P1153
8701877000
P31
P496
0000-0002-2215-7952