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Crystal Structure of Mouse Thymidylate Synthase in Tertiary Complex with dUMP and Raltitrexed Reveals N-Terminus Architecture and Two Different Active Site ConformationsCrystal structure of phosphoramide-phosphorylated thymidylate synthase reveals pSer127, reflecting probably pHis to pSer phosphotransferProperties of phosphorylated thymidylate synthaseCrystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS.Tyrosine nitration affects thymidylate synthase properties.Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N(4)-hydroxy-dCMP.Synthesis and Pharmacological Activity of a New Series of 1-(1H-Indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol AnalogsCrystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenaseThymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMPStructural basis for prolidase deficiency disease mechanismsUnderlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants
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Pools onderzoeker
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0000-0001-7217-4163