Transmembrane Phosphoprotein Cbp Positively Regulates the Activity of the Carboxyl-terminal Src Kinase, Csk
about
Regulation of FynT function by dual domain docking on PAG/CbpThe tyrosine kinase Csk dimerizes through Its SH3 domainDok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.Positive and negative regulation of T-cell activation through kinases and phosphatasesMolecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling UnitsStructure of the carboxyl-terminal Src kinase, CskInteraction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeletonConserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHKReciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatasesPhosphorylation site dynamics of early T-cell receptor signalingPhosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptorProteins at work: a combined small angle X-RAY scattering and theoretical determination of the multiple structures involved on the protein kinase functional landscapeIdentification of N-terminal lobe motifs that determine the kinase activity of the catalytic domains and regulatory strategies of Src and Csk protein tyrosine kinases.C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain.Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains.Actin depolymerization transduces the strength of B-cell receptor stimulationActivation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor.Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturationThe ubiquitously expressed Csk adaptor protein Cbp is dispensable for embryogenesis and T-cell development and functionTransmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts.Positive and negative regulation of T-cell activation by adaptor proteins.The role of the protein tyrosine phosphatase CD45 in regulation of B lymphocyte activation.Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase.Regulation of B-cell signal transduction by adaptor proteins.Regulation of ack-family nonreceptor tyrosine kinases.The roles of membrane microdomains (rafts) in T cell activation.Transmembrane adapters: attractants for cytoplasmic effectors.Negative feedback of T cell activation through inhibitory adapters and costimulatory receptors.Roles of raft-anchored adaptor Cbp/PAG1 in spatial regulation of c-Src kinase.Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding proteinCooperative role of caveolin-1 and C-terminal Src kinase binding protein in C-terminal Src kinase-mediated negative regulation of c-Src.PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.Positive and negative adaptors in T-cell signalling.Transmembrane adaptor proteins: organizers of immunoreceptor signalling.Creating order from chaos: cellular regulation by kinase anchoring.Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.Laminin alters fyn regulatory mechanisms and promotes oligodendrocyte development.Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells.Structural elements and allosteric mechanisms governing regulation and catalysis of CSK-family kinases and their inhibition of Src-family kinases.
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Transmembrane Phosphoprotein Cbp Positively Regulates the Activity of the Carboxyl-terminal Src Kinase, Csk
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Juli 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в липні 2000
@uk
name
Transmembrane Phosphoprotein C ...... boxyl-terminal Src Kinase, Csk
@en
Transmembrane Phosphoprotein C ...... boxyl-terminal Src Kinase, Csk
@nl
type
label
Transmembrane Phosphoprotein C ...... boxyl-terminal Src Kinase, Csk
@en
Transmembrane Phosphoprotein C ...... boxyl-terminal Src Kinase, Csk
@nl
prefLabel
Transmembrane Phosphoprotein C ...... boxyl-terminal Src Kinase, Csk
@en
Transmembrane Phosphoprotein C ...... boxyl-terminal Src Kinase, Csk
@nl
P2093
P2860
P356
P1476
Transmembrane Phosphoprotein C ...... boxyl-terminal Src Kinase, Csk
@en
P2093
Akira Ogawa
Keiko Tamura
Masato Okada
Satoru Takeuchi
Yoshiharu Takayama
P2860
P304
29183-29186
P356
10.1074/JBC.C000326200
P407
P577
2000-07-28T00:00:00Z