Site-specific Mutations in HIV-1 gp41 Reveal a Correlation between HIV-1-mediated Bystander Apoptosis and Fusion/Hemifusion
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HIV-1 induced bystander apoptosisStructures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common ThemeViremic HIV infected individuals with high CD4 T cells and functional envelope proteins show anti-gp41 antibodies with unique specificity and functionViral envelope protein folding and membrane hemifusion are enhanced by the conserved loop region of HIV-1 gp41.Caveolin-1 modulates HIV-1 envelope-induced bystander apoptosis through gp41.Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue.HIV entry and envelope glycoprotein-mediated fusionCell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T CellsTargeting the HIV entry, assembly and release pathways for anti-HIV gene therapy.HIV ENV glycoprotein-mediated bystander apoptosis depends on expression of the CCR5 co-receptor at the cell surface and ENV fusogenic activityTargeting HIV-1 gp41-induced fusion and pathogenesis for anti-viral therapyMacroautophagy Regulation during HIV-1 Infection of CD4+ T Cells and Macrophages.CCR5 antagonist TD-0680 uses a novel mechanism for enhanced potency against HIV-1 entry, cell-mediated infection, and a resistant variant.Synthesis, gp120 binding and anti-HIV activity of fatty acid esters of 1,1-linked disaccharides.Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1HIV-1 envelope glycoprotein-mediated fusion and pathogenesis: implications for therapy and vaccine development.Role of HIV Gp41 mediated fusion/hemifusion in bystander apoptosis.Altered bystander apoptosis induction and pathogenesis of enfuvirtide-resistant HIV type 1 Env mutantsGenetic signatures of HIV-1 envelope-mediated bystander apoptosis.Conditional Cytotoxic Anti-HIV Gene Therapy for Selectable Cell Modification.Evaluation of the cytopathicity (fusion/hemifusion) of patient-derived HIV-1 envelope glycoproteins comparing two effector cell lines.The fusion protein of respiratory syncytial virus triggers p53-dependent apoptosis.Host and Viral Factors in HIV-Mediated Bystander Apoptosis.The HR2 polymorphism N140I in the HIV-1 gp41 combined with the HR1 V38A mutation is associated with a less cytopathic phenotype.Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized miceShort-term additional enfuvirtide therapy is associated with a greater immunological recovery in HIV very late presenters: a controlled pilot study.Specific enfuvirtide-associated mutational pathways in HIV-1 Gp41 are significantly correlated with an increase in CD4(+) cell count, despite virological failure.53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope.The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope.Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection.
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Site-specific Mutations in HIV-1 gp41 Reveal a Correlation between HIV-1-mediated Bystander Apoptosis and Fusion/Hemifusion
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im April 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
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wetenschappelijk artikel
@nl
наукова стаття, опублікована у квітні 2007
@uk
name
Site-specific Mutations in HIV ...... poptosis and Fusion/Hemifusion
@en
Site-specific Mutations in HIV ...... poptosis and Fusion/Hemifusion
@nl
type
label
Site-specific Mutations in HIV ...... poptosis and Fusion/Hemifusion
@en
Site-specific Mutations in HIV ...... poptosis and Fusion/Hemifusion
@nl
prefLabel
Site-specific Mutations in HIV ...... poptosis and Fusion/Hemifusion
@en
Site-specific Mutations in HIV ...... poptosis and Fusion/Hemifusion
@nl
P2093
P2860
P356
P1476
Site-specific Mutations in HIV ...... poptosis and Fusion/Hemifusion
@en
P2093
Anjali Joshi
Eric O. Freed
Himanshu Garg
Robert Blumenthal
P2860
P304
16899-16906
P356
10.1074/JBC.M701701200
P407
P577
2007-04-06T00:00:00Z