about
PML promotes MHC class II gene expression by stabilizing the class II transactivatorThe miR-125a and miR-320c are potential tumor suppressor microRNAs epigenetically silenced by the polycomb repressive complex 2 in multiple myelomaGenome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains.Epigenetics in multiple myeloma: From mechanisms to therapy.Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity
P50
Q24299467-6D5A75F4-8739-401C-B913-0A0DFD663F56Q33838260-1BE7F1F6-ECCE-4B3D-BF68-8B7255764CFAQ36916348-BCEFDB2E-7CC4-4D30-9463-A15B5BC9D9A1Q37705811-335B12BB-3493-402B-B68D-C8091930D2BCQ47101382-EE62B480-9A69-4283-8184-91502528289AQ47922834-B3AED4A0-C972-461E-9881-A8D61B356E3AQ91561742-79C8FC97-319A-4BBE-A660-12C822600AA1
P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Mohammad Alzrigat
@ast
Mohammad Alzrigat
@en
Mohammad Alzrigat
@es
Mohammad Alzrigat
@nl
type
label
Mohammad Alzrigat
@ast
Mohammad Alzrigat
@en
Mohammad Alzrigat
@es
Mohammad Alzrigat
@nl
prefLabel
Mohammad Alzrigat
@ast
Mohammad Alzrigat
@en
Mohammad Alzrigat
@es
Mohammad Alzrigat
@nl
P106
P31
P496
0000-0001-5514-8625