Structural Insights into the ATP Binding Pocket of the Anaplastic Lymphoma Kinase by Site-Directed Mutagenesis, Inhibitor Binding Analysis, and Homology Modeling
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Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophoreALK and ROS1 as a joint target for the treatment of lung cancer: a reviewHomology modeling a fast tool for drug discovery: current perspectives.Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.The emerging role of ALK inhibitors in the treatment of advanced non-small cell lung cancer.Efficacy of crizotinib inhibiting specific molecular pathways in non-small-cell lung carcinoma.PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas.Assessment of the transforming potential of novel anaplastic lymphoma kinase point mutants.Inimitable Imatinib: the range of targeted tumours expands to include T-cell lymphoma.Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors.
P2860
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P2860
Structural Insights into the ATP Binding Pocket of the Anaplastic Lymphoma Kinase by Site-Directed Mutagenesis, Inhibitor Binding Analysis, and Homology Modeling
description
article
@en
im September 2006 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 2006
@uk
name
Structural Insights into the A ...... nalysis, and Homology Modeling
@en
Structural Insights into the A ...... nalysis, and Homology Modeling
@nl
type
label
Structural Insights into the A ...... nalysis, and Homology Modeling
@en
Structural Insights into the A ...... nalysis, and Homology Modeling
@nl
prefLabel
Structural Insights into the A ...... nalysis, and Homology Modeling
@en
Structural Insights into the A ...... nalysis, and Homology Modeling
@nl
P2093
P356
P1476
Structural insights into the A ...... nalysis, and homology modeling
@en
P2093
Leonardo Scapozza
Luca Mologni
Marc Gasser
Roberta Sottocornola
Rosalind H Gunby
Sara Redaelli
Shaheen Ahmed
Valentina Belloni
P304
P356
10.1021/JM060380K
P407
P577
2006-09-01T00:00:00Z