Early IFNγ-Mediated and Late Perforin-Mediated Suppression of Pathogenic CD4 T Cell Responses Are Both Required for Inhibition of Demyelinating Disease by CNS-Specific Autoregulatory CD8 T Cells

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Early IFNγ-Mediated and Late Perforin-Mediated Suppression of Pathogenic CD4 T Cell Responses Are Both Required for Inhibition of Demyelinating Disease by CNS-Specific Autoregulatory CD8 T Cells

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wetenschappelijk artikel

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наукова стаття, опублікована у 2018

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Early IFNγ-Mediated and Late P ...... fic Autoregulatory CD8 T Cells

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Early IFNγ-Mediated and Late P ...... fic Autoregulatory CD8 T Cells

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Early IFNγ-Mediated and Late P ...... fic Autoregulatory CD8 T Cells

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Early IFNγ-Mediated and Late P ...... fic Autoregulatory CD8 T Cells

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Early IFNγ-Mediated and Late P ...... fic Autoregulatory CD8 T Cells

@en

Early IFNγ-Mediated and Late P ...... fic Autoregulatory CD8 T Cells

@nl

P1476

Early IFNγ-Mediated and Late P ...... fic Autoregulatory CD8 T Cells

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Alexander W Boyden

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Ashley A Brate

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Nitin J Karandikar

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P2860

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells.

Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen.

Initiation and exacerbation of autoimmune demyelination of the central nervous system via virus-induced molecular mimicry: implications for the pathogenesis of multiple sclerosis.

Immune regulatory CNS-reactive CD8+T cells in experimental autoimmune encephalomyelitis.

Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma.

Neuroantigen-specific autoregulatory CD8+ T cells inhibit autoimmune demyelination through modulation of dendritic cell function.

The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis

Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis

Regulation of IFN-gamma signaling is essential for the cytotoxic activity of CD8(+) T cells

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2336

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scholarly article

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10.3389/FIMMU.2018.02336

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English

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P577

2018-01-01T00:00:00Z

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30356717

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6189364

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