Combinatorial Control of Prion Protein Biogenesis by the Signal Sequence and Transmembrane Domain
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Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.PrP conformational transitions alter species preference of a PrP-specific antibody.Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel.Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.Arenavirus stable signal peptide is the keystone subunit for glycoprotein complex organization.Cell-specific metabolism and pathogenesis of transmembrane prion protein.Conformational control through translocational regulation: a new view of secretory and membrane protein folding.Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesionPrion protein biosynthesis and its emerging role in neurodegeneration.Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cellsCotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex.PrP charge structure encodes interdomain interactionsPrion protein glycosylation.Substrate-specific function of the translocon-associated protein complex during translocation across the ER membranePrion neurotoxicity: insights from prion protein mutantsNeurotoxic species in prion disease: a role for PrP isoforms?Cytosolic prion protein is the predominant anti-Bax prion protein form: exclusion of transmembrane and secreted prion protein forms in the anti-Bax functionArchitecture, function and prediction of long signal peptides.Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3.Protection from cytosolic prion protein toxicity by modulation of protein translocation.Lysosomal Quality Control in Prion Diseases.Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes.The signal peptide of the ebolavirus glycoprotein influences interaction with the cellular lectins DC-SIGN and DC-SIGNR.Mammalian Prion protein expression in yeast; a model for transmembrane insertionGenetic variability of the coding region for the prion protein gene (PRNP) in gayal (Bos frontalis).Prion protein gene (PRNP) polymorphisms in native Chinese cattle.Cooperativity and flexibility of cystic fibrosis transmembrane conductance regulator transmembrane segments participate in membrane localization of a charged residue.Bison PRNP genotyping and potential association with Brucella spp. seroprevalence.Signal sequences initiate the pathway of maturation in the endoplasmic reticulum lumen.Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection.The corticotropin-releasing factor receptor type 2a contains an N-terminal pseudo signal peptide.The VCP-UBXN1 complex mediates triage of ubiquitylated cytosolic proteins bound to the BAG6 complex.A Transmembrane Form of the Prion Protein Is Localized in the Golgi Apparatus of Neurons
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P2860
Combinatorial Control of Prion Protein Biogenesis by the Signal Sequence and Transmembrane Domain
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Mai 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в травні 2001
@uk
name
Combinatorial Control of Prion ...... uence and Transmembrane Domain
@en
Combinatorial Control of Prion ...... uence and Transmembrane Domain
@nl
type
label
Combinatorial Control of Prion ...... uence and Transmembrane Domain
@en
Combinatorial Control of Prion ...... uence and Transmembrane Domain
@nl
prefLabel
Combinatorial Control of Prion ...... uence and Transmembrane Domain
@en
Combinatorial Control of Prion ...... uence and Transmembrane Domain
@nl
P2860
P356
P1476
Combinatorial control of prion ...... uence and transmembrane domain
@en
P2860
P304
26132-26140
P356
10.1074/JBC.M101638200
P407
P577
2001-05-18T00:00:00Z